Autoimmune conditions following mRNA (BNT162b2) and inactivated (CoronaVac) COVID-19 vaccination: A descriptive cohort study among 1.1 million vaccinated people in Hong Kong

  1. Xue Li
  2. Le Gao
  3. Xinning Tong
  4. Vivien K.Y. Chan
  5. Celine S.L. Chui
  6. Francisco T.T. Lai
  7. Carlos K.H. Wong
  8. Eric Y.F. Wan
  9. Esther W.Y. Chan
  10. Kui Kai Lau
  11. Chak Sing Lau
  12. Ian C.K. Wong

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Abstract

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  1. Version published to 10.1016/j.jaut.2022.102830
  2. ScreenIT

    SciScore for 10.1101/2021.10.21.21265314: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: Ethics: Ethical approval for this study was granted by the Institutional Review Board of the University of Hong Kong/ Hospital Authority Hong Kong West Cluster (UW 21-149 and UW 21-138); and the Department of Health Ethics Committee (LM 21/2021).
    Consent: Patient identification was anonymized from HA and DH databases and patient consent was not required.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Outcome measures: We assessed the incidence of hospital admission related to a spectrum of 16 pre-specified AID, grouped by body systems including: 1) immune-mediated cardiovascular diseases (Kawasaki disease, single organ cutaneous vasculitis); 2) organ specific immune-mediated endocrine disorder (subacute thyroiditis); 3) immune-mediated hematological diseases (anti-phospholipid antibody syndrome, idiopathic thrombocytopenia); 4) immune-mediated multisystem diseases (Sjogren syndrome, systemic lupus erythematosus); 5) immune-mediated musculoskeletal diseases (acute aseptic arthritis, reactive arthritis, rheumatoid arthritis, psoriatic arthritis, spondyloarthritis); and 6) immune-mediated neurological disorders (acute disseminated encephalomyelitis, Guillain-Barré syndrome, narcolepsy and related disorders, and transverse myelitis).
    anti-phospholipid
    suggested: None

    Results from OddPub: Thank you for sharing your code.

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    There are also limitations in this study. Due to limited data sources, our case definition was restricted to autoimmune conditions that were severe enough to warrant hospitalization and inpatient care. Mild, self-limiting autoimmune conditions not requiring inpatient treatment are beyond the scope of this study. Similarly, our EMRs database does not include health information from the private sector, and information on other vaccination which may cause such diseases. Finally, case identification largely depended on ICD-9-CM diagnosis codes, which could cast some uncertainty on coding practices and affirmative diagnosis. However, previous studies using the EMRs database from the HA showed high coding accuracy16-19 and our additional analyses using both primary and secondary diagnosis would minimize this risk.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.10.21.21265314v1 on medRxiv