Clinical Suspicion of COVID-19 in Nursing Home Residents: Symptoms and Mortality Risk Factors

  1. Jeanine J.S. Rutten
  2. Anouk M. van Loon
  3. Janine van Kooten
  4. Laura W. van Buul
  5. Karlijn J. Joling
  6. Martin Smalbrugge
  7. Cees M.P.M. Hertogh

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Abstract

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  1. Version published to 10.1016/j.jamda.2020.10.034
  2. ScreenIT

    SciScore for 10.1101/2020.10.28.20221333: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Ethics: The Medical Ethics Committee of the Amsterdam Medical Center reviewed and approved the study protocol.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    MATLAB then automatically searched the open text fields in which the physicians registered the medical history.
    MATLAB
    suggested: (MATLAB, RRID:SCR_001622)
    All analyses were performed with the use of the SPSS statistical package, version 20·0 (IBM, Illinois, US).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study had several limitations. Based on the Verenso guideline, we assumed that follow-up diagnostics consists of a RT-PCR test. A RT-PCR test has relatively low sensitivity (63-78%).26 Consequently it could be that the group of residents where COVID-19 was ruled-out partly consisted of residents who actually had COVID-19. Moreover, the group of residents where COVID-19 was ruled out did have symptoms, which also may have caused by other underlying infections such as influenza or other viruses. It would be useful to conduct an additional case-control study in which a cohort of residents with confirmed covid-19 would be compared with a pre-COVID-19 era cohort to compare the mortality outcomes. Secondly, our study was set up in the very early stages of the COVID-19 outbreak in the Netherlands (18th March, 2020) and our standardized assessment form was created with available knowledge at the time. As a result, not all relevant symptoms were listed in the standard form. However, we included a question about delirium/confusion/drowsiness in the standardized form, since we hypothesized that NH residents could have atypical presentations. Moreover, physicians had the opportunity to report other symptoms in an open text field, and did so for 32% of the participants in this study. Of note, because of the shortage of RT-PCR tests in the beginning of the epidemic in the Netherlands, initially only residents who met the criteria as described in the Verenso guidelines (i.e. residents ...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.10.28.20221333v1 on medRxiv