The Effects of ARBs, ACEis, and Statins on Clinical Outcomes of COVID-19 Infection Among Nursing Home Residents
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Abstract
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SciScore for 10.1101/2020.05.11.20096347: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This retrospective study conformed with all legal guidelines and the protocol was approved by the Ethical Committee of the Ghent University Hospital (reference BC-07671). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Data were enriched with ATC codes for the included drugs. ATCsuggested: NoneAll statistical analyses were performed using SAS 9.4 (SAS Institute, North Carolina, United States) and RStudio 3.5.2 (R Foundation for Statistical Computing, Vienna, Austria). SAS Institutesuggested: (Statistical Analysis System, RRID:SCR_00856…SciScore for 10.1101/2020.05.11.20096347: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This retrospective study conformed with all legal guidelines and the protocol was approved by the Ethical Committee of the Ghent University Hospital (reference BC-07671). Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Data were enriched with ATC codes for the included drugs. ATCsuggested: NoneAll statistical analyses were performed using SAS 9.4 (SAS Institute, North Carolina, United States) and RStudio 3.5.2 (R Foundation for Statistical Computing, Vienna, Austria). SAS Institutesuggested: (Statistical Analysis System, RRID:SCR_008567)RStudiosuggested: (RStudio, RRID:SCR_000432)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:One limitation of our study is its relatively small cohort size. Consequently, absence of statistical significance should be interpreted with caution. However, the consistency in the observed effect sizes, even without statistical significance due to small sample size, should be considered in the overall evaluation. As number of cases increase, further analyses will be undertaken to better understand our findings and confirm these associations. Also, another limitation was the lack of other potential confounders, including chronic kidney injury and BMI. Finally, our results apply to a very specific population (elderly people living in nursing homes) and cannot be generalized to other groups such as young people or hospitalized people.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04348695 Recruiting Study of Ruxolitinib Plus Simvastatin in the Prevention and … NCT04343001 Withdrawn Coronavirus Response - Active Support for Hospitalised Covid… NCT04351581 Recruiting Effects of Discontinuing Renin-angiotensin System Inhibitors… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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