The Effects of ARBs, ACEis, and Statins on Clinical Outcomes of COVID-19 Infection Among Nursing Home Residents

  1. Anton De Spiegeleer
  2. Antoon Bronselaer
  3. James T. Teo
  4. Geert Byttebier
  5. Guy De Tré
  6. Luc Belmans
  7. Richard Dobson
  8. Evelien Wynendaele
  9. Christophe Van De Wiele
  10. Filip Vandaele
  11. Diemer Van Dijck
  12. Dan Bean
  13. David Fedson
  14. Bart De Spiegeleer

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Abstract

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  1. Version published to 10.1016/j.jamda.2020.06.018
  2. ScreenIT

    SciScore for 10.1101/2020.05.11.20096347: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This retrospective study conformed with all legal guidelines and the protocol was approved by the Ethical Committee of the Ghent University Hospital (reference BC-07671).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Data were enriched with ATC codes for the included drugs.
    ATC
    suggested: None
    All statistical analyses were performed using SAS 9.4 (SAS Institute, North Carolina, United States) and RStudio 3.5.2 (R Foundation for Statistical Computing, Vienna, Austria).
    SAS Institute
    suggested: (Statistical Analysis System, RRID:SCR_008567)
    RStudio
    suggested: (RStudio, RRID:SCR_000432)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    One limitation of our study is its relatively small cohort size. Consequently, absence of statistical significance should be interpreted with caution. However, the consistency in the observed effect sizes, even without statistical significance due to small sample size, should be considered in the overall evaluation. As number of cases increase, further analyses will be undertaken to better understand our findings and confirm these associations. Also, another limitation was the lack of other potential confounders, including chronic kidney injury and BMI. Finally, our results apply to a very specific population (elderly people living in nursing homes) and cannot be generalized to other groups such as young people or hospitalized people.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    NCT04348695RecruitingStudy of Ruxolitinib Plus Simvastatin in the Prevention and …
    NCT04343001WithdrawnCoronavirus Response - Active Support for Hospitalised Covid…
    NCT04351581RecruitingEffects of Discontinuing Renin-angiotensin System Inhibitors…

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.05.11.20096347v1 on medRxiv