Frailty and Mortality in Hospitalized Older Adults With COVID-19: Retrospective Observational Study

  1. Robert De Smet
  2. Bea Mellaerts
  3. Hannelore Vandewinckele
  4. Peter Lybeert
  5. Eric Frans
  6. Sara Ombelet
  7. Wim Lemahieu
  8. Rolf Symons
  9. Erwin Ho
  10. Johan Frans
  11. Annick Smismans
  12. Michaël R. Laurent

Reviewed by

Read the full article

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1016/j.jamda.2020.06.008
  2. ScreenIT

    SciScore for 10.1101/2020.05.26.20113480: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIACUC: Ethics: The Ethical Committee approved the research protocol and waived the need for informed consent, since it did not constitute a clinical study according to national and European regulations.
    Consent: Ethics: The Ethical Committee approved the research protocol and waived the need for informed consent, since it did not constitute a clinical study according to national and European regulations.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    All analyses were performed using GraphPad Prism v8.4.2.
    GraphPad Prism
    suggested: (GraphPad Prism, RRID:SCR_002798)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    However, we recognize several limitations, mainly due to our retrospective study design. Since data were obtained retrospectively from electronic health records, missing data (e.g. for CT-scan or biochemical parameters) may have introduced bias, and follow-up was limited. However, selection bias is unlikely, since we included consecutive cases in a country with universal health coverage. Caution should be applied to extrapolate findings from this single-center study to other healthcare settings. The associations we observed may not be causally related. Despite our robust findings on the association between frailty and mortality, some analyses were likely underpowered due to our modest sample size. We chose not to include patients with so-called “radiographically confirmed” COVID-19 i.e. with typical clinical features and radiographic evidence on chest CT, but with repeatedly negative SARS-CoV-2 RT-PCR. However, only three such patients were excluded, which is unlikely to have influenced the results. Many instruments to determine frailty are available.29 We applied the CFS, which has been adopted in several national COVID-19 triage policies, most notably by U.K. NICE guidelines.11 Previous research has shown that CFS scores can reliably be obtained in critically ill patients based on chart review, patient interview and/or family interview.30 However, we recommend further research to ascertain the reproducibility and reliability before widespread implementation of the CFS durin...

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.05.26.20113480v1 on medRxiv