Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19
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SciScore for 10.1101/2021.01.14.21249801: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Healthy volunteers and patients: Healthy donor blood samples were obtained from the NIHR Cambridge BioResource and leukapheresis samples from the National Health Service Blood and Transfusion services (NHSBT, Cambridge) with written informed consent of donors and approval of the National Research Ethics Committee and Health Research Authority.
IRB: Healthcare workers and patients with Covid-19 confirmed by Nucleic acid amplification testing18 of nasopharyngeal swabs for SARS-CoV-2 were consented to the NIHR Covid-19 cohort of the NIHR BioResource (https://cambridgebrc.nihr.ac.uk/bioresourcecovid19/) with approval of the National Research Ethics …SciScore for 10.1101/2021.01.14.21249801: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement Consent: Healthy volunteers and patients: Healthy donor blood samples were obtained from the NIHR Cambridge BioResource and leukapheresis samples from the National Health Service Blood and Transfusion services (NHSBT, Cambridge) with written informed consent of donors and approval of the National Research Ethics Committee and Health Research Authority.
IRB: Healthcare workers and patients with Covid-19 confirmed by Nucleic acid amplification testing18 of nasopharyngeal swabs for SARS-CoV-2 were consented to the NIHR Covid-19 cohort of the NIHR BioResource (https://cambridgebrc.nihr.ac.uk/bioresourcecovid19/) with approval of the National Research Ethics Committee and Health Research Authority.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable For neutrophil proteomic studies peripheral venous blood was taken from healthy volunteers (age 25 – 60, one female) with written informed and approval of the University of Edinburgh Centre for Inflammation Research Blood Resource Management Committee. Table 2: Resources
Software and Algorithms Sentences Resources Flow cytometry data were analysed using FlowJo (Tree Star, USA). FlowJosuggested: (FlowJo, RRID:SCR_008520)Graphs and statistics were generated using GraphPad Prism software. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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