Cell-type-resolved quantitative proteomics map of interferon response against SARS-CoV-2
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SciScore for 10.1101/2020.08.28.271684: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:One limitation of our study is that the analysis is restricted to cell lines, which may not be physiologically representative of the human tissue, contrary to organoids, but we still provide an overview of the complexity and …
SciScore for 10.1101/2020.08.28.271684: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:One limitation of our study is that the analysis is restricted to cell lines, which may not be physiologically representative of the human tissue, contrary to organoids, but we still provide an overview of the complexity and variability of the interaction between SARS-CoV2 and the human cellular targets. Furthermore, we restricted our proteomics study to 24hpi and more detailed time kinetics experiments are required to elucidate better the dynamic changes occurring during infection. In conclusion, we identify several cell lines of human origin that could be used as physiologically relevant cell models to study the biological properties of SARS-CoV-2. Type-I interferon is commonly regulated during infection in cell lines originating from lungs, colon and liver and warrants more mechanistic studies to identify factors that could be utilized to control the infection.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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