Common variants at 21q22.3 locus influence MX1 and TMPRSS2 gene expression and susceptibility to severe COVID-19
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SciScore for 10.1101/2020.12.18.20248470: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Assessment of the functional role of the SNPs: Candidate regulatory SNPs were explored by HaploReg (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php) (10). HaploRegsuggested: (HaploReg, RRID:SCR_006796)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed …SciScore for 10.1101/2020.12.18.20248470: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Assessment of the functional role of the SNPs: Candidate regulatory SNPs were explored by HaploReg (https://pubs.broadinstitute.org/mammals/haploreg/haploreg.php) (10). HaploRegsuggested: (HaploReg, RRID:SCR_006796)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04343976 Enrolling by invitation Pegylated Interferon Lambda Treatment for COVID-19 NCT04385095 Recruiting Trial of Inhaled Anti-viral (SNG001) for SARS-CoV-2 (COVID-1… NCT04354259 Recruiting Interferon Lambda for Immediate Antiviral Therapy at Diagnos… NCT04293887 Not yet recruiting Efficacy and Safety of IFN-α2β in the Treatment of Novel Cor… NCT04344600 Recruiting Peginterferon Lambda-1a for the Prevention and Treatment of … NCT04320238 Recruiting Experimental Trial of rhIFNα Nasal Drops to Prevent 2019-nCO… NCT04388709 Withdrawn Interferon Lambda Therapy for COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
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