Targeting androgen regulation of TMPRSS2 and ACE2 as a therapeutic strategy to combat COVID-19
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SciScore for 10.1101/2020.10.16.342782: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of the study: Androgen plays a vital role in the human immune response, which we did not address in this paper. Research aimed at characterizing the androgen axis in context with SARS-CoV-2 infection will continue in …
SciScore for 10.1101/2020.10.16.342782: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of the study: Androgen plays a vital role in the human immune response, which we did not address in this paper. Research aimed at characterizing the androgen axis in context with SARS-CoV-2 infection will continue in the future.
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04397718 Recruiting Hormonal Intervention for the Treatment in Veterans With COV… NCT04446429 Completed Anti-Androgen Treatment for COVID-19 NCT04374279 Withdrawn Trial to Promote Recovery From COVID-19 With Endocrine Thera… NCT04475601 Recruiting Enzalutamide Treatment in COVID-19 NCT04353284 Recruiting Camostat Mesylate in COVID-19 Outpatients NCT04470544 Recruiting Camostat Mesilate Treating Patients With Hospitalized Patien… NCT04374019 Recruiting Novel Agents for Treatment of High-risk COVID-19 Positive Pa… NCT04355052 Recruiting Open Label Study to Compare Efficacy, Safety and Tolerabilit… NCT04321096 Active, not recruiting The Impact of Camostat Mesilate on COVID-19 Infection Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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