Burden of COVID-19 and case fatality rate in Pune, India: an analysis of the first and second wave of the pandemic

  1. Prasad Bogam
  2. Aparna Joshi
  3. Sanket Nagarkar
  4. Divyashri Jain
  5. Nikhil Gupte
  6. LS Shashidhara
  7. Joy Merwin Monteiro
  8. Vidya Mave

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Abstract

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  1. Version published to 10.1016/j.ijregi.2021.12.006
  2. ScreenIT

    SciScore for 10.1101/2021.06.21.21259225: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The Indian Institute of Science Education and Research ethics committee, Pune, India, approved this analysis of the public health monitoring program.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    In addition, multiple investigational therapies were advised as ad-hoc, including remdesivir (an antiviral agent), convalescent plasma therapy, and tocilizumab (an anti-interleukin-6 monoclonal antibody) as off label treatment for COVID-19 for moderate disease.
    antiviral agent
    suggested: None
    anti-interleukin-6
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Despite these limitations, to our knowledge, this is the first real-world epidemiologic analysis of the progression of the pandemic and related mortality in a COVID-19 hotspot city, one of many such affected cities in India. In conclusion, we demonstrate that as the burden of COVID-19 expanded from the first wave to the second wave, the CFR declined. Our report suggests the role of evolving therapeutics in the reduction of CFT, but further confirmation is needed. In addition, investigation of the impact of predominant circulating strains on mortality is urgently required. Notably, our report highlights the need for healthcare preparedness, including hospital beds, oxygenation, ventilator support, and health care workers to manage the pandemic of this scale worldwide. Further, there is an urgent need to investigate newer or repurposed therapies and implement mass vaccinations to halt the morbidity and mortality of the devastating COVID-19 pandemic in India and worldwide.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.06.21.21259225v1 on medRxiv