Comparison of antibody response durability of mRNA-1273, BNT162b2, and Ad26.COV2.S SARS-CoV-2 vaccines in healthcare workers
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SciScore for 10.1101/2022.01.14.22269297: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication Authentication: Methods for the cPASS surrogate virus neutralization test (SVNT) were previously published, validated, and shown to be 100% sensitive and specific when compared to gold standard, plaque reduction neutralization test (PRNT), with qualitative analysis results 100% in agreement. Table 2: Resources
Antibodies Sentences Resources Anti-S antibody tests were performed by Bassett Medical Center’s Laboratory using the Abbott AdviseDx Anti-Ssuggested: NoneAnti-N antibody tests were also performed by Bassett’s laboratory using the SARS-CoV-2 … SciScore for 10.1101/2022.01.14.22269297: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication Authentication: Methods for the cPASS surrogate virus neutralization test (SVNT) were previously published, validated, and shown to be 100% sensitive and specific when compared to gold standard, plaque reduction neutralization test (PRNT), with qualitative analysis results 100% in agreement. Table 2: Resources
Antibodies Sentences Resources Anti-S antibody tests were performed by Bassett Medical Center’s Laboratory using the Abbott AdviseDx Anti-Ssuggested: NoneAnti-N antibody tests were also performed by Bassett’s laboratory using the SARS-CoV-2 IgG Abbott Architect assay (Abbott Laboratories, Abbott Park, Anti-Nsuggested: NoneThe α-RBD nAb test measures a subset of antibodies that can block the interaction between the RBD on the SARS-CoV-2 spike protein and the human host receptor angiotensin-converting enzyme 2 (ACE2). human host receptor angiotensin-converting enzyme 2suggested: NoneACE2suggested: NoneSoftware and Algorithms Sentences Resources Anti-S antibody tests were performed by Bassett Medical Center’s Laboratory using the Abbott AdviseDx Abbottsuggested: (Abbott, RRID:SCR_010477)Anti-N antibody tests were also performed by Bassett’s laboratory using the SARS-CoV-2 IgG Abbott Architect assay (Abbott Laboratories, Abbott Park, Abbott Laboratoriessuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Key study limitations included the following: (1) Our study was observational. We addressed predicted confounders by adjusting for covariates likely to impact results; however, unmeasured confounders (e.g., COVID-19 prevention behavior, vaccine preferences, varying infection rates/exposures, and prevalent variants) may have influenced results. Lack of randomization required standardization of the period during which infection rates and VE were quantified. (2) We did not complete peak antibody assays post-primary vaccination precluding comparisons over time. (3) Analyses of Groups 3-5 were limited by small sample sizes. (4) Significant baseline variable group differences included immunosuppression (higher in Group 5, possibly lowering antibody responses in that group), prior COVID-19 infection rates (higher in Groups 3 and 4, possibly increasing antibody responses in those groups), and time from primary vaccination (higher in Groups 1 and 2, possibly lowering antibody responses in those groups). (5) The study design (with addition of the boosted group) and statistical analysis plan (primary analysis focused on subpopulation of surveyed participants) were modified after initiation of enrollment; however, these changes were prespecified prior to seeing primary outcome data. (6) The boosted group included varying primary vaccination-boosting combinations although BNT162b2-BNT162b2 was predominant (67.9%); and insufficient follow-up time to assess boosting’s effects on VE. (7) Ant...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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