Cost-effectiveness analysis of BNT162b2 COVID-19 booster vaccination in the United States
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SciScore for 10.1101/2021.11.14.21266318: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources We collected the total direct medical costs from hospitalisation for each COVID-19 clinical stage based on the Projected Economic Impact Report of the US Healthcare System and Health System Tracker 26,27. US Healthcaresuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First, our study used a decision-analytic Markov model …
SciScore for 10.1101/2021.11.14.21266318: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources We collected the total direct medical costs from hospitalisation for each COVID-19 clinical stage based on the Projected Economic Impact Report of the US Healthcare System and Health System Tracker 26,27. US Healthcaresuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has several limitations. First, our study used a decision-analytic Markov model and did not account for the dynamic changes of population incidence of COVID-19. Second, we estimated the efficacy of the BNT162b2 booster against the Delta variant based on a synthesis of evidence from real-world data rather than randomised controlled trials. We conducted various sensitivity analyses to account for uncertainty in real-world data and parameter biases. Third, we did not consider the other COVID-19 vaccines (e.g., Moderna or J&J/Janssen) in the US. While the other vaccines, particularly the Moderna vaccine, represents a substantial proportion of COVID-19 vaccines administered in the US, they differ from the BNT162b2 vaccines in efficacy and price. It may not be reasonable to combine different vaccines together. Nevertheless, the BNT162b2 vaccine comprises the largest proportion of all COVID-19 vaccines in the US; thus, the cost-effectiveness result of the BNT162b2 vaccines and boosters would be most policy-relevant. As the latest data showed that the Moderna vaccine could be more effective than the BNT162b2 vaccine in preventing hospitalisations 31, the cost-effectiveness of a booster strategy, in reality, is likely to be more favourable than what we estimated. Fourth, we assumed that the efficacy of COVID-19 vaccines begins to wane in 6 months after full vaccination. In reality, the efficacy of vaccines is more likely to gradually decline without a clear cut-off. This ass...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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