Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry

Article activity feed

1. Version published to 10.1016/j.ijid.2022.01.016

   Mar 1, 2022
2. 

   ScreenIT

   Nov 6, 2021

   SciScore for 10.1101/2021.11.03.21265685: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	Field Sample Permit: This study adheres to the STROBE guidelines (Strengthening the Reporting of Observational Studies in Epidemiology20), and it has been conducted by a protocol approved by the National Commission for Research Ethics21 (CAAE 30350820.5.1001.0008). Consent: Individual informed consent was waived due to the pandemic and to the fact that all data collected was unidentified, gathered through medical records.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Data collection: Data was collected through the analysis of medical records by trained health …

   SciScore for 10.1101/2021.11.03.21265685: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   Ethics	Field Sample Permit: This study adheres to the STROBE guidelines (Strengthening the Reporting of Observational Studies in Epidemiology20), and it has been conducted by a protocol approved by the National Commission for Research Ethics21 (CAAE 30350820.5.1001.0008). Consent: Individual informed consent was waived due to the pandemic and to the fact that all data collected was unidentified, gathered through medical records.
   Sex as a biological variable	not detected.
   Randomization	not detected.
   Blinding	not detected.
   Power Analysis	not detected.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Data collection: Data was collected through the analysis of medical records by trained health professionals or undergraduate students (from Medical and Nursing schools) using Research Data Capture (REDCap) tools.22 In the medical records, data collected concerned demographic and clinical characteristics, comorbidities, medication in use prior to admission, COVID-19 symptoms, clinical evaluation at admission, laboratory and radiological exams, medication used during hospitalization and outcomes.	REDCap suggested: (REDCap, RRID:SCR_003445)

   ---

   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

   ---

   Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:

   Study limitations include its retrospective design, with data being collected by chart review only, and the fact that thyroid disease status was based on patients information given at hospital admission, so it was not possible to know if the hypothyroidism was compensated or not. Nevertheless, to the best of our knowledge, the study has the largest sample of COVID-19 patients with hypothyroidism published so far. TSH and thyroid hormone (T4 and T3) levels were not evaluated during the time of hospitalization and time in the ICU, as this is not recommended during hospitalization due to Covid-19 or other acute diseases is by the health organizations, and it was not our aim to access the effects of NTIS. The assessment of thyroid hormone levels throughout the course of Covid-19 is still challenging due to the possibility of overdiagnosis due to abnormal hormone levels during acute systemic disease. It is important to emphasize that these hormonal changes are adaptive processes and cannot be defined as a disease itself.

   ---

   Results from TrialIdentifier: No clinical trial numbers were referenced.

   ---

   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

   ---

   Results from JetFighter: We did not find any issues relating to colormaps.

   ---

   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

   ---

   Results from scite Reference Check: We found no unreliable references.

   ---

   Read the original source
3. 

   Version published to 10.1101/2021.11.03.21265685v1 on medRxiv

   Nov 3, 2021