No difference in risk of hospitalization between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway
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SciScore for 10.1101/2021.09.02.21263014: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Statistical analysis was performed in Stata version 16 (Stata Corporation, College Station, Texas, US), and R version 4.1.0. Ethics: Ethical approval for this study was granted by Regional Committees for Medical Research Ethics - South East Norway, reference number 249509.
Consent: The need for informed consent was waived by the ethics committee.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources We conducted a cohort study, including cases who tested positive for SARS-CoV-2 between 3 May (week 18) and 15 August (week 32) 2021, who had a national identity number … SciScore for 10.1101/2021.09.02.21263014: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Statistical analysis was performed in Stata version 16 (Stata Corporation, College Station, Texas, US), and R version 4.1.0. Ethics: Ethical approval for this study was granted by Regional Committees for Medical Research Ethics - South East Norway, reference number 249509.
Consent: The need for informed consent was waived by the ethics committee.Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources We conducted a cohort study, including cases who tested positive for SARS-CoV-2 between 3 May (week 18) and 15 August (week 32) 2021, who had a national identity number registered, and who had been infected with the Alpha or Delta variant, confirmed by PCR screening assays or whole genome sequencing (WGS). WGSsuggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are also some limitations with our analysis. While our sample size was marginally larger than the study from Scotland [12], both in terms of number of cases overall and number of Delta cases, our power calculations indicated that our study may be underpowered if Delta was associated with a small increased risk of hospitalisation compared to Alpha (supplementary materials, part 2.2). However, given our estimated aRR and 95%CI, this seems unlikely in our study setting. In addition, the method used to determine underlying comorbidities will likely underestimate the true prevalence, as only individuals that have been in contact with health services are identified. Data on medications used and procedure codes are currently not taken into account, which would improve the definitions and detect more individuals with underlying comorbidities. Finally, it should be noted that the reported main cause of hospitalisation is a clinical assessment. We cannot rule out that COVID-19 may have been a contributing factor to admission for some patients reported as having another main cause of hospitalisation. However, there is no reason to believe that the latter two limitations would differ between patients infected with different variants. We also conducted a sensitivity analysis involving all cases hospitalised regardless of main cause, and our results were robust. Our findings indicate no difference in the risk of hospitalisation for cases infected with the Delta variant of SARS-CoV-2 ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- No funding statement was detected.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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