Country differences in transmissibility, age distribution and case-fatality of SARS-CoV-2: a global ecological analysis
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Abstract
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SciScore for 10.1101/2021.02.17.21251839: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Nonetheless, the low number of country observations for the age- and incidence-standardised CFR models is a limitation, and findings related to CFR are likely subject to significant confounding by poor case ascertainment. Generally, the CFR models fit poorly. The impact of a large number of undiagnosed cases on the CFR, and …
SciScore for 10.1101/2021.02.17.21251839: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Nonetheless, the low number of country observations for the age- and incidence-standardised CFR models is a limitation, and findings related to CFR are likely subject to significant confounding by poor case ascertainment. Generally, the CFR models fit poorly. The impact of a large number of undiagnosed cases on the CFR, and the limitations of its use in an ongoing epidemic are well-known (54). While it is logical that population age is an important determining factor, we cannot conclude this on the basis of our results. Limitations: Related to the ecological design of our study, one of the most important limitations is incomplete ascertainment of cases and deaths due to surveillance quality, testing capacity, and cause-of-death ascertainment, which is likely to be highly-variable among countries. We attempted to control for confounding at the aggregate level, with respect to testing. We controlled for testing performance by adjusting for the population testing rate and testing policy but acknowledge that these measures are themselves subject to bias. Low levels of testing in many low-income countries persist, and may mask the true scale of the epidemic. Indeed, studies point to substantial under-ascertainment of deaths in some countries (55, 56). Furthermore, testing data that are available may overrepresent older and sicker patients. Testing data disaggregated by age, sex, socioeconomic status and geographic location were not publicly available in most countries so that it i...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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