In silico transcriptional analysis of asymptomatic and severe COVID-19 patients reveals the susceptibility of severe patients to other comorbidities and non-viral pathological conditions
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SciScore for 10.1101/2022.04.16.488556: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources 2.1. Dataset and Experimental design: In the current study, we obtained publicly available data (GSE178967) from the NCBI GEO (Gene Expression Omnibus). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)While DESeq2 is a DGE analysis tool that mandates data to be unprocessed read counts as integer values [83]. DESeq2suggested: (DESeq, RRID:SCR_000154)Biological annotation: Subsequently, to understand the biological implication of significantly differentially expression genes obtained from DESeq2 analysis in severe patients, we performed gene enrichment … SciScore for 10.1101/2022.04.16.488556: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources 2.1. Dataset and Experimental design: In the current study, we obtained publicly available data (GSE178967) from the NCBI GEO (Gene Expression Omnibus). Gene Expression Omnibussuggested: (Gene Expression Omnibus (GEO, RRID:SCR_005012)While DESeq2 is a DGE analysis tool that mandates data to be unprocessed read counts as integer values [83]. DESeq2suggested: (DESeq, RRID:SCR_000154)Biological annotation: Subsequently, to understand the biological implication of significantly differentially expression genes obtained from DESeq2 analysis in severe patients, we performed gene enrichment analysis using the Enrichr [101–103]. Enrichrsuggested: (Enrichr, RRID:SCR_001575)A few of the top Gene Set Enrichment terms are, i.e., KEGG Human, WikiPathway KEGGsuggested: (KEGG, RRID:SCR_012773)Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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