“Ventilator-free days” composite outcome in patients with SARS-CoV-2 infection treated with tocilizumab: A retrospective competing risk analysis
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SciScore for 10.1101/2021.04.01.21254794: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The original study was approved by the local institutional review board (IRB) with waiver of consent in view of its retrospective design, both studies observe the general principals outlined by the declaration of Helsinki.
Consent: The original study was approved by the local institutional review board (IRB) with waiver of consent in view of its retrospective design, both studies observe the general principals outlined by the declaration of Helsinki.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable We excluded patients younger than 18 years old, pregnant females, and known pulmonary tuberculosis and human … SciScore for 10.1101/2021.04.01.21254794: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The original study was approved by the local institutional review board (IRB) with waiver of consent in view of its retrospective design, both studies observe the general principals outlined by the declaration of Helsinki.
Consent: The original study was approved by the local institutional review board (IRB) with waiver of consent in view of its retrospective design, both studies observe the general principals outlined by the declaration of Helsinki.Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable We excluded patients younger than 18 years old, pregnant females, and known pulmonary tuberculosis and human immunodeficiency virus (HIV) positive cases. Table 2: Resources
Software and Algorithms Sentences Resources Commercially available software STATA® was used in the analysis (StataCorp. 2017. Stata Statistical Software: STATA®suggested: (Stata, RRID:SCR_012763): StataCorp LLC.). StataCorpsuggested: (Stata, RRID:SCR_012763)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study suffers several limitations, first there is the limitation inherent within the retrospective design and lack of prospective randomization, although propensity score matching partially compensates this defect. Second, the small sample size in our study definitely renders it underpowered, and consequently significant findings to be idea generating and should be interpreted cautiously. Third, we didn’t follow the classical method of propensity score matching, however; this was for justifiable reasons, and the resultant matched groups were similar. Last, several details were overlooked in our study, such as the duration of symptoms before hospitalization, mechanical ventilation, and TCZ treatment, since the main focus of the study was the duration of mechanical ventilation itself and ICU outcome, and those details were published elsewhere (3).
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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