The association of D-dimers with mortality, intensive care unit admission or acute respiratory distress syndrome in patients hospitalized with coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
No abstract available
Article activity feed
-
-
SciScore for 10.1101/2020.06.24.20139600: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Experimental Models: Organisms/Strains Sentences Resources After duplications were removed, the title and abstracts were independently screened by two reviewers (AB and VJ). ABsuggested: RRID:BDSC_203)Software and Algorithms Sentences Resources Literature Search: We carried out an electronic search in Medline (PubMed), Embase, and Cochrane database using the keywords “D-dimer” AND “Coronavirus 2019” OR “COVID 19” OR “SARS-CoV-2” OR “2019-nCoV”, between 2019 and current date (9th April, 2020). Medlinesuggested: (MEDLINE, …SciScore for 10.1101/2020.06.24.20139600: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Experimental Models: Organisms/Strains Sentences Resources After duplications were removed, the title and abstracts were independently screened by two reviewers (AB and VJ). ABsuggested: RRID:BDSC_203)Software and Algorithms Sentences Resources Literature Search: We carried out an electronic search in Medline (PubMed), Embase, and Cochrane database using the keywords “D-dimer” AND “Coronavirus 2019” OR “COVID 19” OR “SARS-CoV-2” OR “2019-nCoV”, between 2019 and current date (9th April, 2020). Medlinesuggested: (MEDLINE, RRID:SCR_002185)Embasesuggested: (EMBASE, RRID:SCR_001650)Cochranesuggested: (Cochrane Library, RRID:SCR_013000)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The major limitation of the studies included was that it is unknown as to when were the d-dimer levels obtained during the course of admission. In addition, there was a significant heterogeneity in the reported results. This was likely due to differences in study size, selection bias, and different stages at which the D-dimer values were measured. Also, since all the studies included have been performed in China, the external validity is lacking. The results of this concise meta-analysis suggest that d-dimer is significantly increased in patients having a worse clinical outcome (all-cause mortality, ICU admission or ARDS). Further studies are required to assess if the serial measurement of d-dimer plays any role in predicting evolution towards a more critical form of disease. Also, it will be imperative to know if anticoagulation therapies are of use in patients with severe COVID 19 disease.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-
