SARS-CoV-2 infection paralyzes cytotoxic and metabolic functions of the immune cells
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
No abstract available
Article activity feed
-
-
-
SciScore for 10.1101/2020.09.04.282780: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics statement: The study protocols were approved by the University of Tübingen, Germany Human Research Ethics Committee (
Consent: All participants provided written informed consent in accordance with the Declaration of Helsinki.Randomization Blood was collected from COVID-19 patients enrolled into two different prospective randomized, placebo-controlled, double blind clinical trials evaluating safety and efficacy of hydroxychloroquine in COVID-19 outpatients (COMIHIY) and hospitalized patients (COV-HCQ). Blinding Blood was collected from COVID-19 patients enrolled into two different prospective randomized, placebo-controlled, double blind clinical trials … SciScore for 10.1101/2020.09.04.282780: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: Ethics statement: The study protocols were approved by the University of Tübingen, Germany Human Research Ethics Committee (
Consent: All participants provided written informed consent in accordance with the Declaration of Helsinki.Randomization Blood was collected from COVID-19 patients enrolled into two different prospective randomized, placebo-controlled, double blind clinical trials evaluating safety and efficacy of hydroxychloroquine in COVID-19 outpatients (COMIHIY) and hospitalized patients (COV-HCQ). Blinding Blood was collected from COVID-19 patients enrolled into two different prospective randomized, placebo-controlled, double blind clinical trials evaluating safety and efficacy of hydroxychloroquine in COVID-19 outpatients (COMIHIY) and hospitalized patients (COV-HCQ). Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Amongst this cohort, 3 persons reported mild fever for 10-11 days and 1 individual reported no fever but found positive for SARS-CoV-2 antibodies. SARS-CoV-2suggested: NoneSoftware and Algorithms Sentences Resources Data were analysed using Flow Jo (Tree Star) and fluorescence minus one controls (FMO) were used for setting up the arbitrary gates for the major cell markers. Flow Josuggested: (FlowJo, RRID:SCR_008520)FACS data were analysed using one-way ANOVA for multiple group comparisons (mild, moderate, convalescent and HC) in GraphPad Prism software. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Metabolites data were analysed with MetaboAnalyst 4.0 software. MetaboAnalystsuggested: (MetaboAnalyst, RRID:SCR_015539)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04340544 Terminated Hydroxychloroquine for the Treatment of Mild COVID-19 Diseas… NCT04342221 Recruiting Hydroxychloroquine for COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
-