IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression

  1. Sujan K. Dhar
  2. Vishnupriyan K
  3. Sharat Damodar
  4. Shashi Gujar
  5. Manjula Das

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Abstract

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  1. Version published to 10.1016/j.heliyon.2021.e06155
  2. Version published to 10.1101/2020.08.15.20175844v2 on medRxiv
  3. ScreenIT

    SciScore for 10.1101/2020.08.15.20175844: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableMeta-regression of SMD of a marker was carried out using mixed-effects model with differences in age and sex (measured as percentage of male patients).

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Literature search was performed in Pubmed, Google Scholar and in preprint archives such as medRxiv, bioRxiv and SSRN library for articles in English published in year 2020 till 31 May 2020.
    Pubmed
    suggested: (PubMed, RRID:SCR_004846)
    Google Scholar
    suggested: (Google Scholar, RRID:SCR_008878)
    bioRxiv
    suggested: (bioRxiv, RRID:SCR_003933)
    One study reported non-severe patient data across two groups(24) which were combined using recommendations in Cochrane Handbook(25) section 6.5.2.10.
    Cochrane Handbook(25
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.08.15.20175844v1 on medRxiv