Interferon-stimulated and metallothionein-expressing macrophages are associated with acute and chronic allograft dysfunction after lung transplantation
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SciScore for 10.1101/2021.06.14.447967: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics statement: The study was approved by University Health Network Research Ethics Board (15-9531).
Consent: All participants provided written informed consent for sample collection and analyses.Sex as a biological variable Study design and patient selection: Six (one female and five male) LT recipients were selected, three with acute lung allograft dysfunction (ALAD, defined as a decrease in the forced expiratory volume in one second [FEV1] by 10% or more from the maximum of the two preceding FEV1 measurements) and three with stable lung function. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Data … SciScore for 10.1101/2021.06.14.447967: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Ethics statement: The study was approved by University Health Network Research Ethics Board (15-9531).
Consent: All participants provided written informed consent for sample collection and analyses.Sex as a biological variable Study design and patient selection: Six (one female and five male) LT recipients were selected, three with acute lung allograft dysfunction (ALAD, defined as a decrease in the forced expiratory volume in one second [FEV1] by 10% or more from the maximum of the two preceding FEV1 measurements) and three with stable lung function. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Software and Algorithms Sentences Resources Data were analysed using packages in R including Seurat for QC, clustering workflow, and sample integration, SingleR for cell annotation, and ClusterProfiler for pathway analysis. ClusterProfilersuggested: (clusterProfiler, RRID:SCR_016884)Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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