How time-scale differences in asymptomatic and symptomatic transmission shape SARS-CoV-2 outbreak dynamics

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Abstract

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  1. SciScore for 10.1101/2022.04.21.22274139: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    NIH rigor criteria are not applicable to paper type.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: Thank you for sharing your code and data.


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study comes with a number of caveats. Throughout, we considered an idealized intervention which reduces transmission rate by a fixed amount, but real interventions will be more complex. Some interventions, such as contact tracing and self-isolation, are more likely to reduce late transmission by symptomatic individuals and therefore lead to bigger differences between symptomatic and asymptomatic individuals. Other interventions, such as frequent mass testing, will have similar effects on symptomatic and asymptomatic individuals by an equal amount but may still have qualitatively different effects from the intervention we considered (which assumes generation interval distributions are not affected by intervention). Nonetheless, major interventions that drove the current pandemic (e.g., social distancing, mask wearing, and vaccination) are expected to be similar to the idealized intervention we considered. As a result, we expect our qualitative result to be broadly applicable in scenarios where asymptomatic individuals transmit for a longer amount of time. Finally, we emphasize that virus-driven correlations (i.e., asymptomatic transmission is more likely to result in asymptomatic infection) are distinct from demographic correlations (i.e., younger individuals are more likely to infect younger individuals due to assortative mixing). We considered these two correlations separately for simplicity, but both correlations may be present in an actual epidemic: that is, young indi...

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


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