Estimating the minimum number of SARS-CoV-2 infected cases needed to detect viral RNA in wastewater: To what extent of the outbreak can surveillance of wastewater tell us?

  1. Pei-Ying Hong
  2. Andri Taruna Rachmadi
  3. David Mantilla-Calderon
  4. Mohsen Alkahtani
  5. Yasir M. Bashawri
  6. Hamed Al Qarni
  7. Kathleen M. O'Reilly
  8. Jianqiang Zhou

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Abstract

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  1. Version published to 10.1016/j.envres.2021.110748
  2. ScreenIT

    SciScore for 10.1101/2020.08.19.20177667: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    No key resources detected.

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Rapid Reviews Infectious Diseases

    Han Xia

    Review 1: "How early into the outbreak can surveillance of SARS-CoV-2 in wastewater tell us?"

    This study explores wastewater surveillance for monitoring COVID-19 outbreaks and identifies the case prevalence required for detecting infection in a hospital setting. The claims are somewhat supported by the data presented, but confounding variables limit policy applications.

  4. Rapid Reviews Infectious Diseases

    Rakesh Mishra, Shivranjani Moharir

    Review 2: "How early into the outbreak can surveillance of SARS-CoV-2 in wastewater tell us?"

    This study explores wastewater surveillance for monitoring COVID-19 outbreaks and identifies the case prevalence required for detecting infection in a hospital setting. The claims are somewhat supported by the data presented, but confounding variables limit policy applications.

  6. Version published to 10.1101/2020.08.19.20177667v1 on medRxiv