Breakthrough SARS-CoV-2 infections in double and triple vaccinated adults and single dose vaccine effectiveness among children in Autumn 2021 in England: REACT-1 study
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SciScore for 10.1101/2021.12.14.21267806: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our surveys have limitations. Although the response rate in REACT-1 has declined steadily from 30.5% in round 1 to its current level of 11.7% in round 15, we use rim weighting to obtain prevalence estimates that are representative of the population of England as a whole. While we obtain vaccination data reported by participants, here we relied on data on vaccination as recorded by the NHS for the ∼87% (round 15) who gave permission to …
SciScore for 10.1101/2021.12.14.21267806: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our surveys have limitations. Although the response rate in REACT-1 has declined steadily from 30.5% in round 1 to its current level of 11.7% in round 15, we use rim weighting to obtain prevalence estimates that are representative of the population of England as a whole. While we obtain vaccination data reported by participants, here we relied on data on vaccination as recorded by the NHS for the ∼87% (round 15) who gave permission to link to their NHS records. This has the advantage of providing accurate information on the date of vaccination and type of vaccine used, both important to avoid errors and biases in estimates of prevalence and vaccine effectiveness, and there is no dependency on participant recall. However, to the extent that those who consent and do not consent to data linkage may differ, it is possible that undetected systematic errors may be introduced (this possibility is lessened by the large proportion of people who do consent to linkage). Finally, we changed the method by which swabs were sent to the laboratory for RT-PCR in the present round, relying on the priority postal service for participants to return their swab (transported in saline solution). In the previous round we tested in a 1:1 randomised fashion either courier pick-up (no cold chain) or priority postal service and found no discernible difference between the two in either positivity rate or Ct values [11]. Prior to that, dry swabs were sent by courier to the laboratory on a cold chain. In c...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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SciScore for 10.1101/2021.10.14.21264965: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has limitations. Since the REACT-1 study began in May 2020, we observed a gradual reduction in response rates from 30.5% in round 1 to 11.7% in round 13. However, in round 14, the response rate increased slightly to 12.2%. This increase, albeit small, is encouraging. It may be that further changes to the survey could further increase participation. The change to using wet swabs in saline solution and the collection of samples …
SciScore for 10.1101/2021.10.14.21264965: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Our study has limitations. Since the REACT-1 study began in May 2020, we observed a gradual reduction in response rates from 30.5% in round 1 to 11.7% in round 13. However, in round 14, the response rate increased slightly to 12.2%. This increase, albeit small, is encouraging. It may be that further changes to the survey could further increase participation. The change to using wet swabs in saline solution and the collection of samples without the cold chain (by post or courier) may well have affected diagnostic sensitivity. We were reassured by the limited differences between the samples collected by post and courier. However, because the exact system used in previous rounds (dry swabs and a sustained cold chain) was not compared within a round, we could not estimate the impact of the new approaches compared to that used in previous rounds. A further limitation is that we do not have perfect data on the vaccination status of all participants. Although consent to data linkage was at a high level (87.5% in round 14) not all participants consent for linkage to their NHS records which include data from the COVID-19 immunization programme. For those who are not linked, data on the dates of vaccination and vaccine type are either missing or less reliable than in the linked data, such that we based our estimates of VE on the subset with linked records. This may introduce a bias to the extent that those who do and do not consent to data linkage may differ in important ways, such as ...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-