Initial observations on age, gender, BMI and hypertension in antibody responses to SARS-CoV-2 BNT162b2 vaccine

  1. Raul Pellini
  2. Aldo Venuti
  3. Fulvia Pimpinelli
  4. Elva Abril
  5. Giovanni Blandino
  6. Flaminia Campo
  7. Laura Conti
  8. Armando De Virgilio
  9. Federico De Marco
  10. Enea Gino Di Domenico
  11. Ornella Di Bella
  12. Simona Di Martino
  13. Fabrizio Ensoli
  14. Diana Giannarelli
  15. Chiara Mandoj
  16. Valentina Manciocco
  17. Paolo Marchesi
  18. Francesco Mazzola
  19. Silvia Moretto
  20. Gerardo Petruzzi
  21. Fabrizio Petrone
  22. Barbara Pichi
  23. Martina Pontone
  24. Jacopo Zocchi
  25. Antonello Vidiri
  26. Branka Vujovic
  27. Giulia Piaggio
  28. Aldo Morrone
  29. Gennaro Ciliberto

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Abstract

No abstract available

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  1. Version published to 10.1016/j.eclinm.2021.100928
  2. Rapid Reviews Infectious Diseases

    Carlota Dobaño

    Review 2: "Obesity may hamper SARS-CoV-2 vaccine immunogenicity"

    This paper presents potentially important information about the effects of obesity on vaccine immunogenecity, but reviewers find that the analysis needs substantial clarification and the claims should be presented in the context of the lack of clinical outcomes data.

  3. Rapid Reviews Infectious Diseases

    Jonathan Hare

    Review 1: "Obesity may hamper SARS-CoV-2 vaccine immunogenicity"

    This paper presents potentially important information about the effects of obesity on vaccine immunogenecity, but reviewers find that the analysis needs substantial clarification and the claims should be presented in the context of the lack of clinical outcomes data.

  5. ScreenIT

    SciScore for 10.1101/2021.02.24.21251664: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIACUC: The study protocol complied with the tenets of the Helsinki declaration and was approved by the institutional scientific ethics committee (protocol RS1463/21).
    Consent: All the enrolled participants met the following inclusion criteria: 1) provided written informed consent 2) age between 18-75 years, 3) health workers employed at the Istituti Fisioterapici Ospitalieri (IFO), 4) vaccinated at the Istituti Fisioterapici Ospitalieri (IFO).
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variableFindings: 248 HWCs were analysed, 158 women (63.7%) and 90 men (36.3%).

    Table 2: Resources

    Antibodies
    SentencesResources
    Quantitative measurement of IgG antibodies against S1/S2 antigens of SARS-CoV-2 was performed with a commercial chemiluminescent immunoassay (The LIAISON® SARS-CoV-2 S1/S2 IgG, test Diasorin, Italy) according to the manufacturer’s instruction.
    S1/S2
    suggested: None
    Figure 2: Levels of anti SARS-CoV-2 spike IgG antibody by BMI classes.
    anti SARS-CoV-2 spike IgG
    suggested: None
    Software and Algorithms
    SentencesResources
    Statistical analysis was done using SPSS Statistics software version 21
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: We found the following clinical trial numbers in your paper:

    IdentifierStatusTitle
    ISRCTN55371988NANA

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  6. Version published to 10.1101/2021.02.24.21251664v1 on medRxiv