Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge
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SciScore for 10.1101/2020.10.15.20205054: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was registered at ClinicalTrials.gov (NCT04510025) and approved in the United Kingdom by the North West Preston Research Ethics Committee (reference 20/NW/0235). Randomization not detected. Blinding 8 MRI Image analysis: All images were analysed quantitatively and qualitatively (by expert radiologist, neuroradiologist, cardiac MRI specialists, neuroimage analysts and physicists) in a blinded fashion. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Brain image processing was carried out using an adapted version of the processing pipeline created for the United Kingdom (UK) … SciScore for 10.1101/2020.10.15.20205054: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: This study was registered at ClinicalTrials.gov (NCT04510025) and approved in the United Kingdom by the North West Preston Research Ethics Committee (reference 20/NW/0235). Randomization not detected. Blinding 8 MRI Image analysis: All images were analysed quantitatively and qualitatively (by expert radiologist, neuroradiologist, cardiac MRI specialists, neuroimage analysts and physicists) in a blinded fashion. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Brain image processing was carried out using an adapted version of the processing pipeline created for the United Kingdom (UK) Biobank brain imaging analysis (https://www.fmrib.ox.ac.uk/ukbiobank/), based around tools from the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) software library [FSL (https://fsl.fmrib.ox.ac.uk/fsl)] (appendix, p3,4). FMRIBsuggested: (FSL, RRID:SCR_002823)Statistical analyses were performed using SPSS Version 26.0 (IBM, Armonk, NY, USA). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Third, limitations in exercise tolerance (CPET and six-minute walk distance) and imaging biomarkers correlated with the extent of persistent inflammation. Deconditioning, symptoms of persistent breathlessness, and fatigue were prominent among patients and interfered with activities of daily living and quality of life. Finally, moderate to severe self-reported depression and anxiety symptoms were more common among patients than controls and were related to the burden of persistent breathlessness at follow-up. Studies examining the temporal evolution of lung abnormalities on serial high-resolution CT scans have revealed that persistent inflammatory changes may be seen in up to 71% of COVID-19 survivors at three months post discharge.7,17 Consistent with this, we observed a high proportion of parenchymal abnormalities on lung MRI, albeit at a lower frequency than that seen on CT. Previous investigations have shown that survivors of SARS pneumonia can be left with more permanent damage to the lungs18 and abnormalities in lung function for months to even years after infection. In our study, 13% of patients exhibited abnormalities on spirometry (FVC) at 2-3 months. Although we were unable to assess diffusion capacity (DLCO) in our patients, our findings are in line with a recent report by Mo and colleagues, who demonstrated similar anomalies on spirometry and additionally described an impairment in DLCO in up to 47% of cases.19 The affinity of SARS-CoV-2 for extra-pulmonary organs ...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04510025 Recruiting Capturing MultiORgan Effects of COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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SciScore for 10.1101/2020.10.15.20205054: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement This study was registered at ClinicalTrials.gov (NCT04510025) and approved in the United Kingdom by the North West Preston Research Ethics Committee (reference 20/NW/0235). Randomization not detected. Blinding 8 MRI Image analysis All images were analysed quantitatively and qualitatively (by expert radiologist, neuroradiologist, cardiac MRI specialists, neuroimage analysts and physicists) in a blinded fashion. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Brain image processing was carried out using an adapted version of the processing pipeline created for the United Kingdom (UK) … SciScore for 10.1101/2020.10.15.20205054: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement This study was registered at ClinicalTrials.gov (NCT04510025) and approved in the United Kingdom by the North West Preston Research Ethics Committee (reference 20/NW/0235). Randomization not detected. Blinding 8 MRI Image analysis All images were analysed quantitatively and qualitatively (by expert radiologist, neuroradiologist, cardiac MRI specialists, neuroimage analysts and physicists) in a blinded fashion. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Software and Algorithms Sentences Resources Brain image processing was carried out using an adapted version of the processing pipeline created for the United Kingdom (UK) Biobank brain imaging analysis (https://www.fmrib.ox.ac.uk/ukbiobank/), based around tools from the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) software library [FSL (https://fsl.fmrib.ox.ac.uk/fsl)] (appendix, p3,4). FMRIBsuggested: (FSL, RRID:SCR_002823)Statistical analyses were performed using SPSS Version 26.0 (IBM, Armonk, NY, USA). SPSSsuggested: (SPSS, RRID:SCR_002865)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
Third, limitations in exercise tolerance (CPET and six-minute walk distance) and imaging biomarkers correlated with the extent of persistent inflammation. Deconditioning, symptoms of persistent breathlessness, and fatigue were prominent among patients and interfered with activities of daily living and quality of life. Finally, moderate to severe self-reported depression and anxiety symptoms were more common among patients than controls and were related to the burden of persistent breathlessness at follow-up. Studies examining the temporal evolution of lung abnormalities on serial high-resolution CT scans have revealed that persistent inflammatory changes may be seen in up to 71% of COVID-19 survivors at three months post discharge.7,17 Consistent with this, we observed a high proportion of parenchymal abnormalities on lung MRI, albeit at a lower frequency than that seen on CT. Previous investigations have shown that survivors of SARS pneumonia can be left with more permanent damage to the lungs18 and abnormalities in lung function for months to even years after infection. In our study, 13% of patients exhibited abnormalities on spirometry (FVC) at 2-3 months. Although we were unable to assess diffusion capacity (DLCO) in our patients, our findings are in line with a recent report by Mo and colleagues, who demonstrated similar anomalies on spirometry and additionally described an impairment in DLCO in up to 47% of cases.19 The affinity of SARS-CoV-2 for extra-pulmonary organs ...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04510025 Recruiting Capturing MultiORgan Effects of COVID-19 Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
About SciScore
SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.
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