Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

  1. Florent Sauve
  2. Sreekala Nampoothiri
  3. Sophie A. Clarke
  4. Daniela Fernandois
  5. Caio Fernando Ferreira Coêlho
  6. Julie Dewisme
  7. Edouard G. Mills
  8. Gaetan Ternier
  9. Ludovica Cotellessa
  10. Cristina Iglesias-Garcia
  11. Helge Mueller-Fielitz
  12. Thibaud Lebouvier
  13. Romain Perbet
  14. Vincent Florent
  15. Marc Baroncini
  16. Ariane Sharif
  17. June Ereño-Orbea
  18. Maria Mercado-Gómez
  19. Asis Palazon
  20. Virginie Mattot
  21. Florence Pasquier
  22. Sophie Catteau-Jonard
  23. Maria Martinez-Chantar
  24. Erik Hrabovszky
  25. Mercé Jourdain
  26. Dominique Deplanque
  27. Annamaria Morelli
  28. Giulia Guarnieri
  29. Laurent Storme
  30. Cyril Robil
  31. François Trottein
  32. Ruben Nogueiras
  33. Markus Schwaninger
  34. Pascal Pigny
  35. Julien Poissy
  36. Konstantina Chachlaki
  37. Claude-Alain Maurage
  38. Paolo Giacobini
  39. Waljit Dhillo
  40. S. Rasika
  41. Vincent Prevot

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Abstract

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  1. Version published to 10.1016/j.ebiom.2023.104784
  2. ScreenIT

    SciScore for 10.1101/2020.06.08.139329: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Materials and Methods Figures S1-S10 Tables S1-S5 Movie 1 References (91-99) Gene expression analysis for ACE2, TMPRSS2 and correlated genes in the brain: Collection and processing of human tissues: Immunofluorescence labeling – Animal brains: Antibody table: Fluorescence-activated cell sorting and real-time quantitative PCR: RTqPCR primer table:
    ACE2
    suggested: None

    Results from OddPub: Thank you for sharing your data.

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.06.08.139329 on bioRxiv