Determinants of early antibody responses to COVID-19 mRNA vaccines in a cohort of exposed and naïve healthcare workers
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2021.09.08.21263232: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Ethics: Written informed consent was obtained from all study participants prior to study initiation.
IRB: The study was approved by the Ethics Committee at HCB (references HCB/2020/0336 and HCB/2021/0196).Sex as a biological variable not detected. Randomization Study design, population and setting: The baseline study population included 578 randomly selected HCW from HCB who delivered care and services directly or indirectly to patients. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Quantification of antibodies to SARS-CoV-2: We measured IgA, IgG and IgM antibody levels (median fluorescence intensity, MFI) to different SARS-CoV-2 antigens … SciScore for 10.1101/2021.09.08.21263232: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: Ethics: Written informed consent was obtained from all study participants prior to study initiation.
IRB: The study was approved by the Ethics Committee at HCB (references HCB/2020/0336 and HCB/2021/0196).Sex as a biological variable not detected. Randomization Study design, population and setting: The baseline study population included 578 randomly selected HCW from HCB who delivered care and services directly or indirectly to patients. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Quantification of antibodies to SARS-CoV-2: We measured IgA, IgG and IgM antibody levels (median fluorescence intensity, MFI) to different SARS-CoV-2 antigens using previously developed assays based on the quantitative suspension array technology Luminex (Supplementary Information) [37, 41]. SARS-CoV-2: We measured IgA, IgGsuggested: NoneIgMsuggested: NoneAntibody avidity was determined as the percentage of IgA and IgG levels against RBD, S and S2 antigens measured incubating samples with a chaotropic agent (urea 4M, 30 min at room temperature) over the IgA and IgG levels measured in the same samples without chaotropic agent. S2suggested: NoneSoftware and Algorithms Sentences Resources Data for each participant were collected and managed using REDCap version 8.8.2 hosted at ISGlobal through a standardized electronic questionnaire as previously described [36]. REDCapsuggested: (REDCap, RRID:SCR_003445)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
Results from scite Reference Check: We found no unreliable references.
-
