Influence of past infection with SARS-CoV-2 on the response to the BNT162b2 mRNA vaccine in health care workers: Kinetics and durability of the humoral immune response

  1. Jesús Ontañón
  2. Joaquín Blas
  3. Carlos de Cabo
  4. Celia Santos
  5. Elena Ruiz-Escribano
  6. Antonio García
  7. Luis Marín
  8. Lourdes Sáez
  9. José Luis Beato
  10. Ramón Rada
  11. Laura Navarro
  12. Caridad Sainz de Baranda
  13. Javier Solera

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Abstract

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  1. Version published to 10.1016/j.ebiom.2021.103656
  2. ScreenIT

    SciScore for 10.1101/2021.05.25.21257788: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsIRB: The study was approved by the local Clinical Ethics Committee (Internal code: 2021-12 EOm).
    Consent: Informed consent was obtained from all volunteers before sampling.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Moreover, to evaluate the persistence of the antibody response, anti-SARS-CoV-2 antibodies were measured again 8 to 10 weeks after the second dose of the vaccine.
    anti-SARS-CoV-2
    suggested: None
    Software and Algorithms
    SentencesResources
    IgG antibody levels against the SARS-CoV-2 spike region that binds to the receptor-binding domain (RBD) was measured using the SARS-CoV-2 IgG II Quant immunoassay in the ARCHITECT i-System (Abbott, Abbott Park, US).
    Abbott
    suggested: (Abbott, RRID:SCR_010477)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Key limitations of these data are: short follow up time, lack of a recognized correlate of protection, small sample size, none of the participants were older than 67 years old and none of them belonged to racial or ethnic minorities. Waning antibody levels have been shown in this and recent studies employing anti-SARS-CoV-2 vaccines10,11 Longer term data collection is necessary to properly assess this phenomenon. We are currently starting gathering data at regular intervals from individuals up until one year post-vaccination. In conclusion, our study shows that 10 months after the disease has passed, the immune system is capable of producing a rapid and powerful secondary antibody response after one single dose of the vaccine. Besides, we found that the second dose does not improve the antibody response in individuals with previous Covid-19 infection. Nonetheless, two months later, the persistence of antibody levels is still higher in the experienced HCWs. These data suggest that immune memory remains for a long time in recovered individuals, and therefore, vaccination in this group could be postponed until immunization of the rest of the population is complete.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2021.05.25.21257788v1 on medRxiv