Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2
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SciScore for 10.1101/2021.05.08.21256866: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: The study was approved by the Swedish Ethical Review Authority, and informed written consent was obtained from all participants. Sex as a biological variable Of these, 149 participants received two doses of BNT162b2 vaccine (36 previously infected participants with median age 52 (IQR 41-62), 86% female, and 113 SARS-CoV-2-naïve participants with median age 53 (IQR 42-58), 86 % women), and 83 participants received a single-dose ChAdOx1 nCoV-19 vaccine (46 participants ≥ 11 months post SARS-CoV-2 infection with median age 49 (IQR 41-60), 83% female, and 37 participants < 11 months post SARS-CoV-2 infection with median age 48 (IQR 40-54), 95 % women). Randomization not detected. Blinding no… SciScore for 10.1101/2021.05.08.21256866: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics Consent: The study was approved by the Swedish Ethical Review Authority, and informed written consent was obtained from all participants. Sex as a biological variable Of these, 149 participants received two doses of BNT162b2 vaccine (36 previously infected participants with median age 52 (IQR 41-62), 86% female, and 113 SARS-CoV-2-naïve participants with median age 53 (IQR 42-58), 86 % women), and 83 participants received a single-dose ChAdOx1 nCoV-19 vaccine (46 participants ≥ 11 months post SARS-CoV-2 infection with median age 49 (IQR 41-60), 83% female, and 37 participants < 11 months post SARS-CoV-2 infection with median age 48 (IQR 40-54), 95 % women). Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources For validation, spike-specific IgG antibodies against SARS-CoV-2 wild type were measured in the same samples using the multiplex antigen bead array (FlexMap3D, Luminex Corp) (10). spike-specific IgGsuggested: NoneSoftware and Algorithms Sentences Resources Analyses were performed using GraphPad Prism 9.1.0 (GraphPad Software, Inc, USA). GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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