Shorter androgen receptor polyQ alleles protect against life-threatening COVID-19 disease in European males

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1. Version published to 10.1016/j.ebiom.2021.103246

   Mar 1, 2021
2. 

   ScreenIT

   Nov 6, 2020

   SciScore for 10.1101/2020.11.04.20225680: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   NIH rigor criteria are not applicable to paper type.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Allele size was established using the Genescan Analysis software.	Genescan Analysis suggested: None
   Reads were mapped to the hg19 reference genome by the Burrow-Wheeler aligner BWA.	BWA suggested: (BWA, RRID:SCR_010910)
   Variants were annotated by ANNOVAR.	ANNOVAR suggested: (ANNOVAR, RRID:SCR_012821)
   The data pre-processing was coded in Python, whereas for the logistic regression model the scikit-learn module with the liblinear coordinate descent optimization algorithm was used.	Python suggested: (IPython, RRID:SCR_001658)

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   Results from OddPub: We did not detect open data. We also did not detect …

   SciScore for 10.1101/2020.11.04.20225680: (What is this?)

   Please note, not all rigor criteria are appropriate for all manuscripts.

   Table 1: Rigor

   NIH rigor criteria are not applicable to paper type.

   Table 2: Resources

   Software and Algorithms
   Sentences	Resources
   Allele size was established using the Genescan Analysis software.	Genescan Analysis suggested: None
   Reads were mapped to the hg19 reference genome by the Burrow-Wheeler aligner BWA.	BWA suggested: (BWA, RRID:SCR_010910)
   Variants were annotated by ANNOVAR.	ANNOVAR suggested: (ANNOVAR, RRID:SCR_012821)
   The data pre-processing was coded in Python, whereas for the logistic regression model the scikit-learn module with the liblinear coordinate descent optimization algorithm was used.	Python suggested: (IPython, RRID:SCR_001658)

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   Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

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   Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

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   Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
   

   Identifier	Status	Title
   NCT04549831	Recruiting	Genetic Bases of COVID-19 Clinical Variability

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   Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

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   Results from JetFighter: We did not find any issues relating to colormaps.

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   Results from rtransparent:

   • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
   • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
   • No protocol registration statement was detected.

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   Read the original source
3. 

   Version published to 10.1101/2020.11.04.20225680v1 on medRxiv

   Nov 5, 2020