Evaluating the effects of cardiometabolic exposures on circulating proteins which may contribute to severe SARS-CoV-2
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SciScore for 10.1101/2020.09.10.20191932: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has several limitations which should be taken into account when interpreting its findings. The current sample sizes of the SARS-CoV-2 GWAS are (as one would expect) relatively modest compared to large-scale GWAS data which MR studies are contemporaneously applied to, meaning that our cis-pQTL analysis is likely underpowered. …
SciScore for 10.1101/2020.09.10.20191932: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This study has several limitations which should be taken into account when interpreting its findings. The current sample sizes of the SARS-CoV-2 GWAS are (as one would expect) relatively modest compared to large-scale GWAS data which MR studies are contemporaneously applied to, meaning that our cis-pQTL analysis is likely underpowered. We analysed severe covid-19 as an outcome to mitigate reported selection bias of cases24 so larger sample sizes of severe SARS-CoV-2 GWAS in the future should improve the statistical power of our approach. Furthermore, although the protein GWAS data is of unprecedented sample size compared to previous large-scale pQTL analyses (n=10,708), it remains comparably modest to the sample sizes of GWAS used to derive instrument for the cardiometabolic exposures in this work. This is exaggerated by the fact that protein MRs are typically conducted using a monogenic instrument and thus genetic instruments are likely to explain a lower proportion of variance in the exposure52. Therefore, although we have undertaken thorough evaluations to interrogate bi-directional relationships between the exposures and proteins in this study, the discrepancies between the samples sizes makes the direction of effect challenging to orient (the majority of exposure instruments were derived using sample sizes of n=~440,000). Finally, although data from plasma pQTL studies provide an exceptional opportunity to leverage instruments for MR studies, it should be noted that seru...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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