Inflammatory but not respiratory symptoms are associated with ongoing upper airway viral shedding in outpatients with uncomplicated COVID-19
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SciScore for 10.1101/2021.03.05.21253011: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization Participants were randomized 1:1 to receive a single subcutaneous injection of Lambda or saline placebo and followed for 28 days. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Peripheral blood was collected for assessment of complete blood count, metabolic panel, and SARS-CoV-2 antibody levels against the SARS-CoV-2 spike receptor binding domain (RBD, Supplementary Methods). SARS-CoV-2suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Natu…
SciScore for 10.1101/2021.03.05.21253011: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization Participants were randomized 1:1 to receive a single subcutaneous injection of Lambda or saline placebo and followed for 28 days. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
Antibodies Sentences Resources Peripheral blood was collected for assessment of complete blood count, metabolic panel, and SARS-CoV-2 antibody levels against the SARS-CoV-2 spike receptor binding domain (RBD, Supplementary Methods). SARS-CoV-2suggested: NoneResults from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There were limitations to this study. This cohort was part of a randomized, placebo-controlled trial, where half the cohort received Lambda and the other half received placebo. The duration of symptoms and viral shedding was nearly identical between the two arms in the primary analysis(8), so we included the entire cohort in order to improve statistical power to perform our analyses. Only 4 (3%) participants in this cohort needed hospitalization and 10 (8.3%) went to the ED for evaluation, compared with an incidence of hospitalization of 2.9-11% in other outpatient trials.(7, 23) This is likely related to study selection criteria, and that recruitment occurred during non-surge conditions when even moderately ill patients were being hospitalized. Median participant age was 36 years, and the cohort was predominantly LatinX, reflecting our local population of COVID-19 cases(24); however, our findings may not be generalizable to other settings. Though there was high retention in the study, 34 participants missed two consecutive daily symptom surveys and were excluded from the symptom cluster analysis. Though we collected symptom data daily for 28 days after enrollment, time of symptom onset was reported retrospectively by participants at enrollment and thus subject to recall bias. Finally, this is a secondary analysis of data from a clinical trial that was not designed for these analyses, so this study should be considered hypothesis-generating. In this cohort of participants wit...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04331899 Active, not recruiting Single-Blind Study of a Single Dose of Peginterferon Lambda-… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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