Evaluation of a rapid antigen test (Panbio™ COVID-19 Ag rapid test device) for SARS-CoV-2 detection in asymptomatic close contacts of COVID-19 patients

  1. Ignacio Torres
  2. Sandrine Poujois
  3. Eliseo Albert
  4. Javier Colomina
  5. David Navarro

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Abstract

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  1. Version published to 10.1016/j.cmi.2020.12.022
  2. ScreenIT

    SciScore for 10.1101/2020.12.01.20241562: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The study was approved by the Hospital Clínico de Valencia (HCU) INCLIVA Research Ethics Committee.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablePatients: A total of 634 consecutive asymptomatic individuals (female, n=355; median age, 37 years; range, 9-87 years) attended at the Clínico-Malvarrosa Health Department (Valencia, Spain) were enrolled between October 16 and November 20, 2020.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    Statistical analyses were performed using SPSS version 25.0 (SPSS, Chicago, IL, USA).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Among its limitations are the relative low number of cases, and the possibility that samples were collected too early after exposure, particularly in non-household contacts, in whom RAD sensitivity was strikingly low. In this sense, Linares et al. [4] reported the sensitivity of the Panbio™ test as very low in close contacts at less than 7 days from exposure. In summary, we found the Panbio™ test to display low sensitivity in asymptomatic contacts of COVID-19 patients. Nevertheless, establishing the optimal timeframe for NP collection in household and non-household contacts seems crucial to accurately determine the sensitivity of the test.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.12.01.20241562 on medRxiv