Outcomes of persons with coronavirus disease 2019 in hospitals with and without standard treatment with (hydroxy)chloroquine
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SciScore for 10.1101/2020.08.14.20173369: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: A waiver for the use of hospital record data was obtained through the Institutional Review Board of Amsterdam UMC; however, patients were given the opportunity to opt out. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are some limitations we need to address. Although health …
SciScore for 10.1101/2020.08.14.20173369: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: A waiver for the use of hospital record data was obtained through the Institutional Review Board of Amsterdam UMC; however, patients were given the opportunity to opt out. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:There are some limitations we need to address. Although health care in the Netherlands has a homogeneous setup, there was some variability in standard protocols among the hospitals that could have led to residual confounding. The two non-(H)CQ-hospitals were tertiary (academic) centres, whereas the (H)CQ-hospitals comprised secondary care hospitals. Since we excluded subjects transferred to and from other hospitals, the referral role of the tertiary care hospitals was minimized. Furthermore, subjects in the (H)CQ hospitals were more likely to receive steroid treatment, while subjects in the non-(H)CQ hospitals were more likely to receive other experimental immunomodulatory drugs. The numbers of the individual types of medication were small, making it impossible to draw conclusions from these differences. The results of the RECOVERY trial (publication pending), suggested a lower mortality in patients treated with dexamethasone. Treatment with dexamethasone could therefore have resulted in a lower mortality in the group of (H)CQ hospitals. We did not find such an effect, even after correction in the full model. We also used extensive covariate adjustments, using various methods to minimize influence of differences in patient population among hospitals, and the similarity in outcomes between these methods is reassuring in this regard. Finally, because not every subject in the (H)CQ-hospitals actually received (H)CQ, the current efficacy estimate in our study is likely an underes...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04261517 Completed Efficacy and Safety of Hydroxychloroquine for Treatment of C… NCT04307693 Terminated Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in P… Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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