Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019

  1. Juliana Cepelowicz Rajter
  2. Michael S. Sherman
  3. Naaz Fatteh
  4. Fabio Vogel
  5. Jamie Sacks
  6. Jean-Jacques Rajter

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  1. ScreenIT

    SciScore for 10.1101/2020.06.06.20124461: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: Oversight: The protocol was approved by the institutional review board for the Broward Health hospital system.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    All statistical analyses were conducted using IBM SPSS v 24.0 software.
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    Our study has several limitations. Due to the retrospective observational nature of the study, despite adjustment for known cofounders, we cannot exclude the possibility of unmeasured confounding factors. Although more of the control group was enrolled earlier in the study, suggesting the possibility of timing bias, this may be offset by preferential treatment of more severe patients with ivermectin early in the study due to low initial availability. We also did not find consistently better mortality outcomes with time over the short duration of this study. Most of our patients studied received hydroxychloroquine with or without azithromycin and we are unable to determine whether these medications had an added benefit, or whether mortality would have been better in both groups without these agents. We have shown that ivermectin administration was significantly associated with lower mortality among patients with COVID-19, particularly in patients with more severe disease. Interpretation of these findings are tempered by the limitations of the retrospective design and the possibility of confounding. Appropriate dosing for this indication is not known; nor are the effects of ivermectin on viral load, or in patients with milder disease. Further studies in appropriately designed randomized trials are recommended before any conclusions can be made.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1016/j.chest.2020.10.009
  3. ScreenIT

    SciScore for 10.1101/2020.06.06.20124461: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementOversight The protocol was approved by the institutional review board for the Broward Health hospital system .RandomizationTh findings require randomized controlled trials for confirmation .Blindingnot detected.Power Analysisnot detected.Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    All statistical analyses were conducted using IBM SPSS v 24.0 software.
    SPSS
    suggested: (SPSS, SCR_002865)

    Results from OddPub: We did not find a statement about open data. We also did not find a statement about open code. Researchers are encouraged to share open data when possible (see Nature blog).

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore is not a substitute for expert review. SciScore checks for the presence and correctness of RRIDs (research resource identifiers) in the manuscript, and detects sentences that appear to be missing RRIDs. SciScore also checks to make sure that rigor criteria are addressed by authors. It does this by detecting sentences that discuss criteria such as blinding or power analysis. SciScore does not guarantee that the rigor criteria that it detects are appropriate for the particular study. Instead it assists authors, editors, and reviewers by drawing attention to sections of the manuscript that contain or should contain various rigor criteria and key resources. For details on the results shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2020.06.06.20124461v2 on medRxiv
  5. Version published to 10.1101/2020.06.06.20124461v1 on medRxiv