Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2
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SciScore for 10.1101/2022.05.17.492220: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Dataset collection: The information on antibodies S24-223, P2B-1E4, 2-7, LY-CoV1404, XG005, XG031, and COV2-2268 were compiled in our previous study [12], whereas the information on XGv042, XGv264, XGv265, and XGv266 were compiled in CoV-AbDab [38]. LY-CoV1404, XG005suggested: NoneAllele assignment of IGHV2-5/IGLV2-14-encoded RBD antibodies: For antibodies P2B-1E4, XG005, and XG031, the allele information was obtained from the original publications [14, 16]. XG031suggested: NoneAll “ambiguous” allele assignments in this … SciScore for 10.1101/2022.05.17.492220: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Table 2: Resources
Antibodies Sentences Resources Dataset collection: The information on antibodies S24-223, P2B-1E4, 2-7, LY-CoV1404, XG005, XG031, and COV2-2268 were compiled in our previous study [12], whereas the information on XGv042, XGv264, XGv265, and XGv266 were compiled in CoV-AbDab [38]. LY-CoV1404, XG005suggested: NoneAllele assignment of IGHV2-5/IGLV2-14-encoded RBD antibodies: For antibodies P2B-1E4, XG005, and XG031, the allele information was obtained from the original publications [14, 16]. XG031suggested: NoneAll “ambiguous” allele assignments in this study came from antibodies that do not have nucleotide sequence information available, namely XGv264, XGv265, and XGv266. XGv266suggested: NoneSoftware and Algorithms Sentences Resources Somatic hypermutations were identified by IgBlast [25]. IgBlastsuggested: (IgBLAST, RRID:SCR_002873)Analysis of CDR H3 sequences: Sequence alignment was performed using MAFFT [40]. MAFFTsuggested: (MAFFT, RRID:SCR_011811)Sequence logos were generated by WebLogo [42]. WebLogosuggested: (WEBLOGO, RRID:SCR_010236)Results from OddPub: Thank you for sharing your code.
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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