SARS-CoV-2 genomic surveillance identifies naturally occurring truncation of ORF7a that limits immune suppression
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SciScore for 10.1101/2021.02.22.21252253: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of Study: The viral replication defect and cellular immune responses presented here were performed using in vitro cell culture. While HEK 293T-hACE2 and Vero E6 cells support virus entry and replication (Cantuti-Castelvetri et al., 2020; Chu et al., 2020), they may not recapitulate particular aspects of an in vivo infection …
SciScore for 10.1101/2021.02.22.21252253: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of Study: The viral replication defect and cellular immune responses presented here were performed using in vitro cell culture. While HEK 293T-hACE2 and Vero E6 cells support virus entry and replication (Cantuti-Castelvetri et al., 2020; Chu et al., 2020), they may not recapitulate particular aspects of an in vivo infection (Takayama, 2020). We anticipate that the in vitro results presented here will provide important context for clinical comparisons, similar to those recently published for ORF8 (Young et al., 2020).
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We found bar graphs of continuous data. We recommend replacing bar graphs with more informative graphics, as many different datasets can lead to the same bar graph. The actual data may suggest different conclusions from the summary statistics. For more information, please see Weissgerber et al (2015).
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
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