Population impact of SARS-CoV-2 variants with enhanced transmissibility and/or partial immune escape
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
SciScore for 10.1101/2021.08.26.21262579: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of the study: An obvious limitation of our model is that it does not allow for circulation of multiple variants in the same population. In reality, variants compete with one another as well as the WT strain, and this may lead to complex behavior that is difficult to predict from pairwise interactions. It is particularly challenging to anticipate the dynamics of a system with multiple variants that each have some degree of enhanced …
SciScore for 10.1101/2021.08.26.21262579: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of the study: An obvious limitation of our model is that it does not allow for circulation of multiple variants in the same population. In reality, variants compete with one another as well as the WT strain, and this may lead to complex behavior that is difficult to predict from pairwise interactions. It is particularly challenging to anticipate the dynamics of a system with multiple variants that each have some degree of enhanced transmissibility and immune escape, as the relative fitness of these strains may flip as the level of immunity in the population increases. Additional modeling is therefore required to understand the threats posed by different variants circulating simultaneously in a single population. Our model is also strictly focused on what happens to a variant following emergence; the phenomenon of emergence itself, which is inherently stochastic, is not considered here. The generation and persistence of novel lineages is related to the size of the infected population, as well as the selective pressures acting on the viral population. The emergence of new variants is therefore affected by control measures, such as nonpharmaceutical interventions and vaccination, that limit the prevalence of infection and alter the strength of selection on different traits [40]. This will be an important dimension to consider in future work, as the optimal strategies to minimize transmission of a particular variant may or may not be aligned with the best strategies t...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-
