The flexibility of ACE2 in the context of SARS-CoV-2 infection
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SciScore for 10.1101/2020.09.16.300459: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources Missing C terminal residues of the ACE2 transmembrane helices were modeled using I-TASSER (49–51) based on the known sequence (residues 769 to 805), while missing N terminal residue coordinates (residues 19 to 21) were copied from 6M0J following alignment of the N terminal helix. I-TASSERsuggested: (I-TASSER, RRID:SCR_014627)Minimization, equilibration and production simulations were performed on the Frontera computing system at the Texas Advanced Computing Center (TACC) using NAMD 2.14 (59), as described in detail in Casalino et al (60). NAMDsuggested: (NAMD, RRID:SCR_014894)Results from Od…
SciScore for 10.1101/2020.09.16.300459: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
NIH rigor criteria are not applicable to paper type.Table 2: Resources
Software and Algorithms Sentences Resources Missing C terminal residues of the ACE2 transmembrane helices were modeled using I-TASSER (49–51) based on the known sequence (residues 769 to 805), while missing N terminal residue coordinates (residues 19 to 21) were copied from 6M0J following alignment of the N terminal helix. I-TASSERsuggested: (I-TASSER, RRID:SCR_014627)Minimization, equilibration and production simulations were performed on the Frontera computing system at the Texas Advanced Computing Center (TACC) using NAMD 2.14 (59), as described in detail in Casalino et al (60). NAMDsuggested: (NAMD, RRID:SCR_014894)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: Please consider improving the rainbow (“jet”) colormap(s) used on page 4. At least one figure is not accessible to readers with colorblindness and/or is not true to the data, i.e. not perceptually uniform.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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