Ethnic disparities in hospitalisation for COVID-19 in England: The role of socioeconomic factors, mental health, and inflammatory and pro-inflammatory factors in a community-based cohort study
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SciScore for 10.1101/2020.05.19.20106344: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: 14 Ethical approval was received from the North-West Multi-centre Research Ethics Committee, and the research was carried out in accordance with the Declaration of Helsinki of the World Medical Association, and participants gave informed consent.
Consent: 14 Ethical approval was received from the North-West Multi-centre Research Ethics Committee, and the research was carried out in accordance with the Declaration of Helsinki of the World Medical Association, and participants gave informed consent.Randomization not detected. Blinding not detected. Power Analysis To maintain statistical power in our analyses, we grouped together Chinese, Mixed and Other under the … SciScore for 10.1101/2020.05.19.20106344: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: 14 Ethical approval was received from the North-West Multi-centre Research Ethics Committee, and the research was carried out in accordance with the Declaration of Helsinki of the World Medical Association, and participants gave informed consent.
Consent: 14 Ethical approval was received from the North-West Multi-centre Research Ethics Committee, and the research was carried out in accordance with the Declaration of Helsinki of the World Medical Association, and participants gave informed consent.Randomization not detected. Blinding not detected. Power Analysis To maintain statistical power in our analyses, we grouped together Chinese, Mixed and Other under the “Other” category. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:The study is not without its weaknesses. First, due to the absence of systematic testing across the UK, these data come from hospital records, therefore reflect only patients with a manifestation of the disease severe enough to require inpatient admission into hospital. Some cases of COVID-19 could also have been captured in patients originally hospitalized for reasons other than the infection. Second, the UK Biobank cohort is not representative of the general UK population. Therefore, absolute prevalence and risks should not be interpreted as such, but an aetiological investigation of risk factor association such as the present study are likely to be generalizable.24 However, it is important to keep in mind that double selection of the sample - UK Biobank participants are not representative from the general population, and we selected a non-missing analytical sample within the cohort - may lead to collider bias.25 This means that conditioning on factors associated with the selection of the sample can distort or induce spurious associations. For example, this is likely to have been the case in studies finding that current smokers appear protected against COVID-19.26 In the present study, smoking (in particular ex-smokers) was associated with greater risk of COVID-19 hospitalization, somewhat ruling out collider bias. Third, despite using an extensive set of socioeconomic factors, both at individual and area level, we failed to capture some features that may be particularly re...
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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