Different efficacies of neutralizing antibodies and antiviral drugs on SARS-CoV-2 Omicron subvariants, BA.1 and BA.2
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SciScore for 10.1101/2022.02.27.482147: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Infection assay was conducted by inoculating VeroE6/TMPRSS2 cells with each SARS-CoV-2 strain at an MOI of 0.003 for 1 h, followed by washing out free viruses and culturing cells with fresh medium. VeroE6/TMPRSS2suggested: JCRB Cat# JCRB1819, RRID:CVCL_YQ49)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected …SciScore for 10.1101/2022.02.27.482147: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Infection assay was conducted by inoculating VeroE6/TMPRSS2 cells with each SARS-CoV-2 strain at an MOI of 0.003 for 1 h, followed by washing out free viruses and culturing cells with fresh medium. VeroE6/TMPRSS2suggested: JCRB Cat# JCRB1819, RRID:CVCL_YQ49)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Limitations of the study: This study was limited to cell culture infection assays, in which cell types and other conditions reflected drug sensitivities. However, viral targeting agents examined in this study (casirivimab, imdevimab, and S309 target Spike, EIDD-1931 target polymerase, and nirmatrelvir target main protease) were much less governed through cellular backgrounds, compared to host-targeting antivirals, and instead are more affected by viral factors such as sequence changes in the viral genome. Our assay at least compared the intrinsic antibody/drug sensitivity of SARS-CoV-2 variants side by side, helpful in discussing the impact of sequence substitutions on antibody/drug activities. Additionally, the analyses of animal and patient infections under treatment were further desired to understand drug efficacy. Yet, given the Omicron BA.2 wave’s urgency and the need for the scientific evidence to better combat this infectious disease, our data significantly present the potential diversity of drug/antibody efficacies among SARS-CoV-2 variants.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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