Virucidal and antiviral activity of astodrimer sodium against SARS-CoV-2 in vitro

  1. Jeremy R.A. Paull
  2. Graham P. Heery
  3. Michael D. Bobardt
  4. Alex Castellarnau
  5. Carolyn A. Luscombe
  6. Jacinth K. Fairley
  7. Philippe A. Gallay

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Abstract

No abstract available

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  3. Version published to 10.1016/j.antiviral.2021.105089
  4. Version published to 10.21203/rs.3.rs-440941/v1 on Research Square
  5. Version published to 10.1101/2020.08.20.260190v2 on bioRxiv
  6. ScreenIT

    SciScore for 10.1101/2020.08.20.260190: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board Statementnot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.
    Cell Line Authenticationnot detected.

    Table 2: Resources

    Experimental Models: Cell Lines
    SentencesResources
    Virus stock was generated at 360Biolabs (Melbourne, Australia) by two passages in Vero cells in virus growth media, which comprised Minimal Essential Medium (MEM) without L-glutamine supplemented with 1% (w/v) L-glutamine, 1.0 μg/mL of L-(tosylamido-2-phenyl)
    Vero
    suggested: None
    Virus and compound mixture were added to Vero E6 cell monolayers in 96-well plates and incubated at 37°C in 5% CO2 for 4 days.
    Vero E6
    suggested: None

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  7. Version published to 10.1101/2020.08.20.260190v1 on bioRxiv