COVID-19 booster dose induces robust antibody response in pregnant, lactating, and nonpregnant women
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SciScore for 10.1101/2022.05.17.22275154: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Participant recruitment and study design: Women at two tertiary care hospitals were approached for enrollment in an Institutional Review Board (IRB)–approved (protocol #2020P003538) COVID-19 pregnancy biorepository study. Sex as a biological variable Participant recruitment and study design: Women at two tertiary care hospitals were approached for enrollment in an Institutional Review Board (IRB)–approved (protocol #2020P003538) COVID-19 pregnancy biorepository study. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources mouse anti-human detection antibodies were added to detect … SciScore for 10.1101/2022.05.17.22275154: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics IRB: Participant recruitment and study design: Women at two tertiary care hospitals were approached for enrollment in an Institutional Review Board (IRB)–approved (protocol #2020P003538) COVID-19 pregnancy biorepository study. Sex as a biological variable Participant recruitment and study design: Women at two tertiary care hospitals were approached for enrollment in an Institutional Review Board (IRB)–approved (protocol #2020P003538) COVID-19 pregnancy biorepository study. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Antibodies Sentences Resources mouse anti-human detection antibodies were added to detect antigen-specific isotype titer (Southern Biotech). mouse anti-human detection antibodiessuggested: Noneanti-human detectionsuggested: Noneantigen-specific isotype titer ( Southern Biotech) .suggested: NoneExperimental Models: Cell Lines Sentences Resources 18 A pseudovirus encoding Omicron Spike was produced by transfecting 293T cells with an Omicron Spike expression plasmid, a lentiviral backbone encoding CMV-Luciferase-IRES-ZsGreen and lentiviral helper plasmids. 293Tsuggested: KCB Cat# KCB 200744YJ, RRID:CVCL_0063)Software and Algorithms Sentences Resources Statistical Analysis: Statistical analysis was performed in R (version 4.0.0) or GraphPad Prism (version 8.0). GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
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