Characteristics of patients referred to a cardiovascular disease clinic for post-acute sequelae of SARS-CoV-2 infection

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Abstract

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  1. SciScore for 10.1101/2021.12.04.21267294: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Ethicsnot detected.
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    No key resources detected.


    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).


    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study should be interpreted in the context of the following limitations. First, referrals and diagnostic evaluation were not systematic, but may be generalizable to other cardiology practices seeing high volumes of patients with PASC. Second, our understanding of PASC evolved with time, and we eventually reduced the number of diagnostic tests consistent with our growing experience that the overwhelming majority of patients with mild acute COVID-19 infection presenting with exertional dyspnea and tachycardia had no cardiovascular disease pathology; still, all patients had a thorough cardiovascular physical exam, ECG, and echocardiogram. Third, the clinical relevance of myocardial involvement based on cardiac MRI is uncertain. Finally, new diagnoses that better define the PASC cardiovascular syndrome may emerge, although diagnostic algorithms have yet to be developed. In conclusion, this study provides insight into patients with cardiovascular manifestations of PASC, emphasizing the need for multidisciplinary teams and accelerated research to better phenotype and treat a heterogeneous group of patients.

    Results from TrialIdentifier: No clinical trial numbers were referenced.


    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.


    Results from JetFighter: We did not find any issues relating to colormaps.


    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    Results from scite Reference Check: We found no unreliable references.


    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.