Almitrine as a non-ventilatory strategy to improve intrapulmonary shunt in COVID-19 patients
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SciScore for 10.1101/2020.05.18.20105502: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This ScvO2 increase provides a greater reserve for O2 extraction in case of acute desaturation, and increased the level of dissolved O2, the diffusible form of oxygen to the tissues.(20) This case control series has several …
SciScore for 10.1101/2020.05.18.20105502: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:This ScvO2 increase provides a greater reserve for O2 extraction in case of acute desaturation, and increased the level of dissolved O2, the diffusible form of oxygen to the tissues.(20) This case control series has several limitations in addition to the small size cohort (17 patients). First, although the “control” COVID-19 patients were selected on stringent criteria to match the studied group, it was not randomized and could be biased. The stability in PaO2 during 8 hours reinforced the credence in an almitrine effect. In absence of a drug shortage, all of these patients would have received almitrine. This shortage resulted from the small national stock of almitrine facing an important demand during the pandemic. Second, although the data were prospectively collected, the overwhelmed care team capabilities in a dramatic context explains why some data were missing. Third, for the same reason, we were not able to administer the drug for a longer period than 36 to 48 hours for few patients. This precludes any conclusion about the potential benefit on mechanical ventilation duration and on the number of prone positioning. Following the same line of thinking, the almitrine test on arterial oxygenation cannot be proposed as either a prognostic test or a predicator of the prone position response. In conclusion, in a case series of early hypoxemic COVID-19 pneumonia with acute respiratory failure, iv almitrine was associated with an improvement in arterial blood oxygenation both i...
Results from TrialIdentifier: We found the following clinical trial numbers in your paper:
Identifier Status Title NCT04380727 Completed Almitrine and COVID-19 Related Hypoxemia Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a protocol registration statement.
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