Assessment of the humoral response to the homologous Gam-COVID-Vac (Sputnik V) or heterologous Sputnik V/mRNA-1273 (Moderna) vaccination against SARS-CoV-2 in dialysis patients

  1. Gustavo Laham
  2. Alfredo P. Martínez
  3. Wanda Rojas Gimenez
  4. Lucas Amaya
  5. Anabel Abib
  6. Natalia Echegoyen
  7. Carlos Díaz
  8. Alicia Lucero
  9. Antonella Martelli
  10. Cristina Videla
  11. Karin Neukam
  12. Federico Alejandro Di Lello

Reviewed by

Read the full article See related articles

Listed in

Log in to save this article

Abstract

No abstract available

Article activity feed

  1. Version published to 10.1007/s40620-022-01446-2
  2. Version published to 10.1101/2022.05.13.22275049v2 on medRxiv
  3. ScreenIT

    SciScore for 10.1101/2022.05.13.22275049: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    EthicsConsent: Ethical Approval and Informed Consent: The study was designed and performed according to the Helsinki declaration and all participants gave their written informed consent (Study protocol EX-2021-06438339-UBA DME#SSA_FFYB, Ethics committee of the Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires).
    IRB: Ethical Approval and Informed Consent: The study was designed and performed according to the Helsinki declaration and all participants gave their written informed consent (Study protocol EX-2021-06438339-UBA DME#SSA_FFYB, Ethics committee of the Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires).
    Sex as a biological variablenot detected.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.

    Table 2: Resources

    Antibodies
    SentencesResources
    Anti-S-RBD antibodies were quantified using the Abbott Diagnostics SARS-CoV-2 IgG II Quant chemiluminescent microparticle immunoassay (CMIA) on an Architect i2000 SR and an Alinity I analyzer (Abbott Diagnostics, Abbott Park, Illinois, USA).
    Anti-S-RBD
    suggested: None
    Software and Algorithms
    SentencesResources
    To standardize the results to WHO binding antibody units (BAU), a correction factor for Abbott arbitrary units (AU) was applied where 1 BAU/mL equals 0.142 AU, as previously established by Abbott with the WHO international standard NIBSC 20– 136 [13-.
    Abbott
    suggested: (Abbott, RRID:SCR_010477)
    Statistical analyses were carried out using the SPSS statistical software package release 23.0 (IBM SPSS Inc., Chicago, IL, USA).
    SPSS
    suggested: (SPSS, RRID:SCR_002865)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has a limitation. It should be considered that serious adverse effects have been reported in a very low frequency and the small size of the analyzed sample might have influenced this aspect. In conclusion, both analyzed vaccine schemes were immunogenic and showed a high seroconversion rate. In addition, a significant correlation was found between higher anti-S-RBD IgG titers and a confirmed prior infection with SARS-CoV-2 for both schemes. Moreover, the heterologous scheme was also associated with a better humoral response. Finally, local and systemic adverse effects were scarce and mostly mild, demonstrating that both schemes are safe and well-tolerated. These findings should promote patients on dialysis to receive these immunization schemes.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a protocol registration statement.

    Results from scite Reference Check: We found no unreliable references.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  4. Version published to 10.1101/2022.05.13.22275049v1 on medRxiv