Clinical Outcomes of Critically III Patients with COVID-19 by Race

  1. Fahad Marmarchi
  2. Michael Liu
  3. Srikant Rangaraju
  4. Sara C. Auld
  5. Maria Christina Creel-Bulos
  6. Christine L Kempton
  7. Milad Sharifpour
  8. Manila Gaddh
  9. Roman Sniecinski
  10. Cheryl L. Maier
  11. Fadi Nahab
  12. The Emory COVID-19 Quality and Clinical Research Collaborative (QCRC)

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Abstract

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  1. Version published to 10.1007/s40615-021-00966-0
  2. ScreenIT

    SciScore for 10.1101/2020.09.07.20190074: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: This study was approved by the Emory University Institutional Review Board.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    This observational cohort study includes data from hospitalized COVID-19 patients admitted from March 6, 2020 to May 5, 2020 who were admitted to Emory Healthcare, a tertiary referral teaching hospital in Atlanta, Georgia.
    Emory Healthcare
    suggested: (One Mind Biospecimen Bank Listing, RRID:SCR_004193)
    Data were collected through June 9, 2020 and analyzed using a chi-square or Wilcoxon rank-sum test for categorical and continuous variables, respectively, with a two-sided p-value of less than 0.05 considered statistically significant (Stata Version 12.1; StataCorp LLC, College Station, TX).
    StataCorp
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:
    This study has some limitations. Our study was limited to three metropolitan Atlanta hospitals within one academic health system in Georgia and may have limited generalizability to other health care settings. However, our study represents a large cohort of critically ill COVID-19 patients including a large proportion of AA patients. Additionally, this study is limited by being a retrospective analysis of an ICU-specific cohort that does not compare mortality rates outside of an ICU setting. Despite these limitations, our study shows similar in-hospital mortality rates between AAs and other races despite AAs having higher rates of comorbidities at admission and higher rates of RRT in the hospital. Whether these findings are due to pre-hospital social factors [6], differences in the disease manifestation or differences in provider treatments requires further study.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  3. Version published to 10.1101/2020.09.07.20190074v1 on medRxiv