SARS-CoV-2 Neutralization in Convalescent Plasma and Commercial Lots of Plasma-Derived Immunoglobulin
This article has been Reviewed by the following groups
Listed in
- Evaluated articles (ScreenIT)
Abstract
Article activity feed
-
-
-
SciScore for 10.1101/2021.08.13.456066: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Cell inoculation was incubated for 1h at 37°C, 5% CO2 in saturated humidity until an additional volume of 20 ml Vero cell culture medium was added. Verosuggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)Software and Algorithms Sentences Resources For statistical analyses, the software GraphPad Prism version 8.4.3 (686) for Windows, GraphPad Software, San Diego, California USA, www.graphpad.com, was used. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)GraphP…SciScore for 10.1101/2021.08.13.456066: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Ethics not detected. Sex as a biological variable not detected. Randomization not detected. Blinding not detected. Power Analysis not detected. Cell Line Authentication not detected. Table 2: Resources
Experimental Models: Cell Lines Sentences Resources Cell inoculation was incubated for 1h at 37°C, 5% CO2 in saturated humidity until an additional volume of 20 ml Vero cell culture medium was added. Verosuggested: CLS Cat# 605372/p622_VERO, RRID:CVCL_0059)Software and Algorithms Sentences Resources For statistical analyses, the software GraphPad Prism version 8.4.3 (686) for Windows, GraphPad Software, San Diego, California USA, www.graphpad.com, was used. GraphPad Prismsuggested: (GraphPad Prism, RRID:SCR_002798)GraphPadsuggested: (GraphPad Prism, RRID:SCR_002798)Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:A further limitation is that here presented data was generated using the D614G variant close to Wuhan wildtype strain, while the pandemic is currently driven by SARS-CoV-2 variants of concern and - interest. However, polyclonality of IVIG/SCIG could render a complete neutralization evasion of variants less likely as compared to monoclonal therapies, while for CP (from one donor, respectively) immune escape of variants of concern from neutralization has been shown of approximately 15x, underscoring the general notion that optimal neutralization/protection is achieved against the isolate that caused the immune response [57]. In a passive immunization setting with IVIG/SCIG, this means not only trailing the epidemiology of donors in terms of neutralizing titer but also in terms of quality, meaning which variants will be neutralized best.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
Results from scite Reference Check: We found no unreliable references.
-