In Search of the SARS-CoV-2 Protection Correlate: Head-to-Head Comparison of Two Quantitative S1 Assays in Pre-characterized Oligo-/Asymptomatic Patients
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Abstract
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SciScore for 10.1101/2021.02.19.21252080: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Commission of the Faculty of Medicine at Ludwig-Maximilians-Universität Munich (20-275-V) and the protocol is available online (www.koco19.de) [20]. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Once established and rigorously validated, these assays may replace the current gold standard of direct neutralization, which requires handling at …
SciScore for 10.1101/2021.02.19.21252080: (What is this?)
Please note, not all rigor criteria are appropriate for all manuscripts.
Table 1: Rigor
Institutional Review Board Statement IRB: The study was approved by the Ethics Commission of the Faculty of Medicine at Ludwig-Maximilians-Universität Munich (20-275-V) and the protocol is available online (www.koco19.de) [20]. Randomization not detected. Blinding not detected. Power Analysis not detected. Sex as a biological variable not detected. Table 2: Resources
No key resources detected.
Results from OddPub: Thank you for sharing your code and data.
Results from LimitationRecognizer: We detected the following sentences addressing limitations in the study:Once established and rigorously validated, these assays may replace the current gold standard of direct neutralization, which requires handling at biosafety level 3 and has severe limitations in signal resolution at the lower end of the range. In this study, both EI-S1-IgG-quant and Ro-RBD-Ig-quant showed a high level of correlation with direct virus micro-neutralization and surrogate neutralization test, GS-cPass. For example, raw values above 28.7 U/mL for Ro-RBD-Ig-quant and above 49.8 U/mL for EI-S1-IgG-quant, respectively, predicted virus neutralization >1:5 in 95% of cases. We may hypothesize that when the value of the quantitative tests is above the predictive value (e.g. 95%), there is little benefit in performing NT and that this could act as a surrogate marker for neutralizing titers e.g., after mass vaccinations or post-infection. Our results suggest that both quantitative assays may be useful in future studies aimed to assess immunization efficiency, determine the degree of herd immunity and estimate how long the response persists over time.
Results from TrialIdentifier: No clinical trial numbers were referenced.
Results from Barzooka: We did not find any issues relating to the usage of bar graphs.
Results from JetFighter: We did not find any issues relating to colormaps.
Results from rtransparent:- Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
- Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
- No protocol registration statement was detected.
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