The Efficacy and Safety of Hydroxychloroquine in Patients with COVID-19: A Multicenter National Retrospective Cohort

  1. Abdulkarim Abdulrahman
  2. Islam AlSayed
  3. Marwa AlMadhi
  4. Jumana AlArayed
  5. Sara Jaafar Mohammed
  6. Aesha Khalid Sharif
  7. Khadija Alansari
  8. Abdulla Ismael AlAwadhi
  9. Manaf AlQahtani

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  1. ScreenIT

    SciScore for 10.1101/2020.11.25.20234914: (What is this?)

    Please note, not all rigor criteria are appropriate for all manuscripts.

    Table 1: Rigor

    Institutional Review Board StatementIRB: The National COVID-19 Research and Ethics Committee has been jointly established by the Ministry of Health and Bahrain Defence Force Hospital research committees in response to the pandemic, to facilitate and monitor COVID-19 research in Bahrain.
    Consent: Informed consent was waived by the National COVID-19 Research and Ethics Committee for this study due to its retrospective and observational nature and the absence of any patient identifying information.
    Randomizationnot detected.
    Blindingnot detected.
    Power Analysisnot detected.
    Sex as a biological variablenot detected.

    Table 2: Resources

    Software and Algorithms
    SentencesResources
    The STATA software, version 15.1, was used to execute the statistical analyses, (StataCorp. 2017. Stata Statistical Software:
    STATA
    suggested: (Stata, RRID:SCR_012763)
    StataCorp
    suggested: (Stata, RRID:SCR_012763)

    Results from OddPub: We did not detect open data. We also did not detect open code. Researchers are encouraged to share open data when possible (see Nature blog).

    Results from LimitationRecognizer: An explicit section about the limitations of the techniques employed in this study was not found. We encourage authors to address study limitations.

    Results from TrialIdentifier: No clinical trial numbers were referenced.

    Results from Barzooka: We did not find any issues relating to the usage of bar graphs.

    Results from JetFighter: We did not find any issues relating to colormaps.

    Results from rtransparent:
    • Thank you for including a conflict of interest statement. Authors are encouraged to include this statement when submitting to a journal.
    • Thank you for including a funding statement. Authors are encouraged to include this statement when submitting to a journal.
    • No protocol registration statement was detected.

    About SciScore

    SciScore is an automated tool that is designed to assist expert reviewers by finding and presenting formulaic information scattered throughout a paper in a standard, easy to digest format. SciScore checks for the presence and correctness of RRIDs (research resource identifiers), and for rigor criteria such as sex and investigator blinding. For details on the theoretical underpinning of rigor criteria and the tools shown here, including references cited, please follow this link.

  2. Version published to 10.1007/s40121-021-00397-8
  3. Version published to 10.1101/2020.11.25.20234914 on medRxiv